Linked Life Data

15157015

Source:http://linkedlifedata.com/resource/pubmed/id/15157015

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-5-25
pubmed:abstractText
The beneficial effects of anionic salts on calcium metabolism have been shown by supplementing rations with such salts during the last 3 weeks of pre-partum. However, there are few reports on the effects of anionic salts supplementation for periods of 4 weeks or longer on acid-base status, mineral metabolism and bone morphology. This study was conducted to evaluate the effects of the long-term dietary supplementation of anionic salts on the acid-base status, plasma minerals concentrations and bone morphology in sheep. Twenty-seven twin-bearing sheep were assigned to two experimental groups and a control group, depending on dietary cation-anion difference (DCAD) (+272.6, -88.9 and + 164.5 mEq/kg DM, respectively). Sheep assigned to each dietary treatment received their respective rations beginning 6 weeks prepartum and continuing until 12 days post-partum. Diets containing anionic salts induced a mild metabolic hyperchloraemic acidosis from 1 week pre-partum to 2 days post-partum that was completely compensated by non-respiratory mechanisms. These changes on acid-base status were accompanied by an increase of plasma ionized calcium levels. Plasma total calcium, phosphorus and magnesium concentrations were not affected by dietary treatment. Parathyroid hormone concentrations were related to the concentration of ionized calcium of plasma and were higher in sheep fed the cationic diet. Plasma osteocalcin levels were increased in sheep fed the anionic diet and cortical bone remodelling occurred in all the animals during late pregnancy in light and electron microscopy observation, but was particularly evident in the sheep fed the anionic diet. Bone turnover might be stimulated because of the role of the bone in buffering systemic acidosis. The data suggest that anionic salts ameliorated calcium metabolism around parturition by increasing bone resorption and the concentration of ionised calcium in plasma, possibly mediated by a mild hyperchloraemic metabolic acidosis induced by the salts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0931-184X
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
488-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Long-term effects of dietary anion-cation balance on acid-base status and bone morphology in reproducing ewes.
pubmed:affiliation
Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria, Campus Universitario s/n, 27002 Lugo, Spain. lespino@lugo.usc.es
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't