| pubmed-article:15156431 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15156431 | lifeskim:mentions | umls-concept:C0442592 | lld:lifeskim |
| pubmed-article:15156431 | lifeskim:mentions | umls-concept:C0588202 | lld:lifeskim |
| pubmed-article:15156431 | lifeskim:mentions | umls-concept:C1579762 | lld:lifeskim |
| pubmed-article:15156431 | lifeskim:mentions | umls-concept:C0009491 | lld:lifeskim |
| pubmed-article:15156431 | lifeskim:mentions | umls-concept:C0442529 | lld:lifeskim |
| pubmed-article:15156431 | lifeskim:mentions | umls-concept:C1963724 | lld:lifeskim |
| pubmed-article:15156431 | lifeskim:mentions | umls-concept:C1521801 | lld:lifeskim |
| pubmed-article:15156431 | lifeskim:mentions | umls-concept:C2700386 | lld:lifeskim |
| pubmed-article:15156431 | lifeskim:mentions | umls-concept:C0724128 | lld:lifeskim |
| pubmed-article:15156431 | pubmed:dateCreated | 2004-5-24 | lld:pubmed |
| pubmed-article:15156431 | pubmed:abstractText | Methadone-maintenance treatment clinics are strategically appealing sites for provision of directly administered antiretroviral therapy (DAART) to human immunodeficiency virus type 1 (HIV-1)-infected injection drug users (IDUs). We initiated an ongoing DAART protocol at a university-associated methadone clinic in April 2001, which continues to enroll participants. Participants ingested antiretroviral medications under direct supervision on days they attended the clinic; evening doses and doses on "methadone take-home days" were self-administered. Comparison IDUs receiving either standard care or treatment-adherence support were randomly selected from the population of the HIV-1 clinic where DAART participants received their primary care for HIV-1 infection, with frequency matching by sex, prior antiretroviral exposure, and receipt of methadone therapy. In an intention-to-treat analysis, 79% of DAART participants achieved HIV-1 RNA levels of <400 copies/mL by month 6 of therapy, compared with 54% in the standard care group (P=.035) and 48% in the adherence support group (P=.008). The preliminary results of this study both suggest that DAART can be feasible and acceptable to patients in a methadone clinic setting and provide impetus for further study of this treatment strategy in randomized controlled trials. | lld:pubmed |
| pubmed-article:15156431 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15156431 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15156431 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15156431 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15156431 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15156431 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15156431 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15156431 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15156431 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15156431 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15156431 | pubmed:issn | 1537-6591 | lld:pubmed |
| pubmed-article:15156431 | pubmed:author | pubmed-author:MooreRichard... | lld:pubmed |
| pubmed-article:15156431 | pubmed:author | pubmed-author:LucasGregory... | lld:pubmed |
| pubmed-article:15156431 | pubmed:author | pubmed-author:WeidlePaul... | lld:pubmed |
| pubmed-article:15156431 | pubmed:author | pubmed-author:HaderShannonS | lld:pubmed |
| pubmed-article:15156431 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15156431 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15156431 | pubmed:volume | 38 Suppl 5 | lld:pubmed |
| pubmed-article:15156431 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15156431 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15156431 | pubmed:pagination | S409-13 | lld:pubmed |
| pubmed-article:15156431 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15156431 | pubmed:meshHeading | pubmed-meshheading:15156431... | lld:pubmed |
| pubmed-article:15156431 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15156431 | pubmed:articleTitle | Directly administered antiretroviral therapy in an urban methadone maintenance clinic: a nonrandomized comparative study. | lld:pubmed |
| pubmed-article:15156431 | pubmed:affiliation | Johns Hopkins University, Baltimore, MD 21287, USA. glucas@jhmi.edu | lld:pubmed |
| pubmed-article:15156431 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15156431 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:15156431 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15156431 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
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