|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011860,
umls-concept:C0017262,
umls-concept:C0026845,
umls-concept:C0028754,
umls-concept:C0032529,
umls-concept:C0044707,
umls-concept:C0185117,
umls-concept:C0206131,
umls-concept:C0332281,
umls-concept:C0332307,
umls-concept:C1551488,
umls-concept:C2911684
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|
pubmed:issue |
6
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|
pubmed:dateCreated |
2004-6-28
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|
pubmed:abstractText |
The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) modulates tissue-specific glucocorticoid concentrations by generating active cortisol. We have shown that adipose tissue 11beta-HSD1 mRNA levels were associated with adiposity and insulinaemia. Here we conducted further expression and genetic association studies in Pima Indians.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0012-186X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1088-95
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15156315-11-beta-Hydroxysteroid Dehydrogenase Type 1,
pubmed-meshheading:15156315-Adipocytes,
pubmed-meshheading:15156315-Adult,
pubmed-meshheading:15156315-Arizona,
pubmed-meshheading:15156315-Body Mass Index,
pubmed-meshheading:15156315-Diabetes Mellitus, Type 2,
pubmed-meshheading:15156315-Female,
pubmed-meshheading:15156315-Gene Expression Profiling,
pubmed-meshheading:15156315-Genotype,
pubmed-meshheading:15156315-Great Britain,
pubmed-meshheading:15156315-Humans,
pubmed-meshheading:15156315-Indians, North American,
pubmed-meshheading:15156315-Infusions, Intravenous,
pubmed-meshheading:15156315-Insulin,
pubmed-meshheading:15156315-Insulin Resistance,
pubmed-meshheading:15156315-Male,
pubmed-meshheading:15156315-Muscle, Skeletal,
pubmed-meshheading:15156315-Obesity,
pubmed-meshheading:15156315-Polymorphism, Single Nucleotide
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|
pubmed:year |
2004
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pubmed:articleTitle |
11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle.
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pubmed:affiliation |
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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