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rdf:type |
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lifeskim:mentions |
umls-concept:C0023693,
umls-concept:C0026649,
umls-concept:C0162740,
umls-concept:C0242769,
umls-concept:C0871261,
umls-concept:C0871269,
umls-concept:C1314939,
umls-concept:C1551336,
umls-concept:C1704259,
umls-concept:C1704632,
umls-concept:C1705987,
umls-concept:C1706817,
umls-concept:C1820370,
umls-concept:C2911692
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pubmed:issue |
6
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pubmed:dateCreated |
2004-6-4
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pubmed:abstractText |
SPINDLY (SPY) is a negative regulator of gibberellin signaling in Arabidopsis thaliana that also functions in previously undefined pathways. The N terminus of SPY contains a protein-protein interaction domain consisting of 10 tetratricopeptide repeats (TPRs). GIGANTEA (GI) was recovered from a yeast two-hybrid screen for proteins that interact with the TPR domain. GI and SPY also interacted in Escherichia coli and in vitro pull-down assays. The phenotypes of spy and spy-4 gi-2 plants support the hypothesis that SPY functions with GI in pathways controlling flowering, circadian cotyledon movements, and hypocotyl elongation. GI acts in the long-day flowering pathway upstream of CONSTANS (CO) and FLOWERING LOCUS T (FT). Loss of GI function causes late flowering and reduces CO and FT RNA levels. Consistent with SPY functioning in the long-day flowering pathway upstream of CO, spy-4 partially suppressed the reduced abundance of CO and FT RNA and the late flowering of gi-2 plants. Like gi, spy affects the free-running period of cotyledon movements. The free-running period was lengthened in spy-4 mutants and shortened in plants that overexpress SPY under the control of the 35S promoter of Cauliflower mosaic virus. When grown under red light, gi-2 plants have a long hypocotyl. This hypocotyl phenotype was suppressed in spy-4 gi-2 double mutants. Additionally, dark-grown and far-red-light-grown spy-4 seedlings were found to have short and long hypocotyls, respectively. The different hypocotyl length phenotypes of spy-4 seedlings grown under different light conditions are consistent with SPY acting in the GA pathway to inhibit hypocotyl elongation and also acting as a light-regulated promoter of elongation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10069079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10469647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10477524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10517866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10542233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10550633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10583960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10583961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10753899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10799287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10801981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-10834834,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-11121080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-11269319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-11283341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-11323677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-11457967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-11457975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-11842176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-11851908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-11951029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-12045270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-12045273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-12068105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-12136030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-12177480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-12511023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-7855595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-7855596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-7994182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-8220456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-8400871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-8799194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-8819329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-9181432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-9242909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-9342315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155885-9504934
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CONSTANS protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FT protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/GI protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Plant,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SPY protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1040-4651
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 American Society of Plant Biologists
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1550-63
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:15155885-Movement,
pubmed-meshheading:15155885-Light,
pubmed-meshheading:15155885-Mutation,
pubmed-meshheading:15155885-Flowers,
pubmed-meshheading:15155885-Cotyledon,
pubmed-meshheading:15155885-Time Factors,
pubmed-meshheading:15155885-RNA, Messenger,
pubmed-meshheading:15155885-Protein Binding,
pubmed-meshheading:15155885-Protein Structure, Tertiary,
pubmed-meshheading:15155885-Repressor Proteins,
pubmed-meshheading:15155885-Signal Transduction,
pubmed-meshheading:15155885-RNA, Plant,
pubmed-meshheading:15155885-DNA-Binding Proteins,
pubmed-meshheading:15155885-Arabidopsis,
pubmed-meshheading:15155885-Transcription Factors
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