Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-5-24
pubmed:abstractText
Listeria infection during pregnancy can cause the death of both mother and fetus. Previous studies established that immunostimulatory CpG oligodeoxynucleotides (ODN) increase the resistance of healthy adult mice to many infectious pathogens, including Listeria monocytogenes. This study examines whether the innate immune response elicited by CpG ODN can reduce the susceptibility of pregnant mice to lethal listeria challenge. The results indicate that CpG ODN treatment significantly improves maternal survival and reduces pathogen transmission to offspring. CpG ODN administered during pregnancy did not induce abortion, birth defects, or reduce the size or health of litters. These findings suggest that CpG ODN may provide a safe and effective means of improving the health of mothers and fetuses during pregnancy.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-10485647, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-10531213, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-11130078, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-11179339, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-11432815, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-11477402, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-11564765, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-11748176, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-11861616, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-11865436, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-12119352, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-12388699, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-12817010, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-12970451, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-1376349, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-1960706, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-3086677, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-6395269, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-6541701, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-7621071, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-7700380, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-8363725, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-8409418, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-8456301, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-8476559, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-8543816, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-8548847, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-8610135, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9125353, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9252886, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9256274, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9284372, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9344498, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9357139, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9558060, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9682382, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9725240, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9794366, http://linkedlifedata.com/resource/pubmed/commentcorrection/15155663-9973506
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3543-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection.
pubmed:affiliation
Section of Retroviral Immunology, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.