| pubmed-article:1515551 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1515551 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:1515551 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:1515551 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:1515551 | lifeskim:mentions | umls-concept:C0006506 | lld:lifeskim |
| pubmed-article:1515551 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:1515551 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:1515551 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1515551 | pubmed:dateCreated | 1992-10-7 | lld:pubmed |
| pubmed-article:1515551 | pubmed:abstractText | The effect of commonly used food antioxidants on recombinant tumor necrosis factor alpha (rTNF-alpha)-induced cytotoxicity, growth enhancement and adhesion has been evaluated. Butylated hydroxyanisole (BHA) and 4-hydroxymethyl-2,6-di-t-butylphenol (HBP) were the only two of nine antioxidants that completely inhibited rTNF-alpha-induced cytotoxicity in L929 and WEHI 164 fibrosarcoma cells. Ethoxyquin, propyl gallate and butylated hydroquinone only partially inhibited rTNF-alpha-induced cytotoxicity, while the antioxidants butylated hydroxytoluene (BHT), alpha-tocopherol, ascorbic acid and thiodipropionic acid had minimal effects. The only difference between the molecular structure of the efficient HBP and the non-efficient BHT, is a hydroxymethyl group instead of a hydroxyl group on the phenolic ring. Neither BHA nor BHT inhibited the activation of NF kappa B after 10 or 60 min challenge with rTNF-alpha in L929 cells. BHA also inhibited rTNF-alpha-induced, but not rIL-1 beta-induced growth enhancement in FS-4 fibroblasts. Further, BHA blocked both rTNF-alpha-induced and rIL-1 beta-induced prostaglandin E2 synthesis in FS-4 fibroblasts. BHA inhibited the rTNF-alpha-induced release of arachidonic acid in both FS-4 and L929 cells, suggesting that BHA inhibits cellular phospholipase(s). Neither alpha-tocopherol nor BHA inhibited rTNF-alpha-induced adhesiveness of human endothelial cells. The results indicate that BHA is a specific and potent inhibitor of rTNF-alpha- and rTNF-beta-induced cytotoxicity, as well as of rTNF-alpha-induced growth enhancement. | lld:pubmed |
| pubmed-article:1515551 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1515551 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1515551 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1515551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1515551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1515551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1515551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1515551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1515551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1515551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1515551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1515551 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1515551 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1515551 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:1515551 | pubmed:author | pubmed-author:BrekkeO LOL | lld:pubmed |
| pubmed-article:1515551 | pubmed:author | pubmed-author:BjerveK SKS | lld:pubmed |
| pubmed-article:1515551 | pubmed:author | pubmed-author:ShalabyM RMR | lld:pubmed |
| pubmed-article:1515551 | pubmed:author | pubmed-author:EspevikTT | lld:pubmed |
| pubmed-article:1515551 | pubmed:author | pubmed-author:SundanAA | lld:pubmed |
| pubmed-article:1515551 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1515551 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:1515551 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1515551 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1515551 | pubmed:pagination | 269-80 | lld:pubmed |
| pubmed-article:1515551 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1515551 | pubmed:meshHeading | pubmed-meshheading:1515551-... | lld:pubmed |
| pubmed-article:1515551 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1515551 | pubmed:articleTitle | Butylated hydroxyanisole specifically inhibits tumor necrosis factor-induced cytotoxicity and growth enhancement. | lld:pubmed |
| pubmed-article:1515551 | pubmed:affiliation | Department of Clinical Chemistry, Trondheim Regional Hospital, University of Norway. | lld:pubmed |
| pubmed-article:1515551 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1515551 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1515551 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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