Linked Life Data

15155006

Source:http://linkedlifedata.com/resource/pubmed/id/15155006

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-5-24
pubmed:abstractText
Period aftereffects are a form of behavioral plasticity in which the free-running period of circadian behavior undergoes experience-dependent changes. It is unclear whether this plasticity is age dependent and whether the changes in behavioral period relate to changes in the SCN or the retina, 2 known circadian pacemakers in mammals. To determine whether these changes vary with age, Per1-luc transgenic mice (in which the luciferase gene is driven by the Period1 promoter) of different ages were exposed to short (10 h light: 10 h dark, T20) or long (14 h light: 14 h dark, T28) light cycles (T cycles). Recordings of running-wheel activity in constant darkness (DD) revealed that the intrinsic periods of T20 mice were significantly shorter than of T28 mice at all ages. Aftereffects following the shorter light cycle were significantly smaller in mice older than 3 months, corresponding with a decreased ability to entrain to T20. Age did not diminish entrainment or aftereffects in the 28-h light schedule. The behavioral period of pups born in DD depended on the T cycle experienced in utero, showing maternal transference of aftereffects. Recordings of Per1-luc activity from the isolated SCN in vitro revealed that the SCN of young mice expressed aftereffects, but the periods of behavior and SCN were negatively correlated. Enucleation in DD had no effect on behavioral aftereffects, indicating the eyes are not required for aftereffects expression. These data show that circadian aftereffects are an age-dependent form of plasticity mediated by stable changes in the SCN and, importantly, extra-SCN tissues.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0748-7304
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
198-207
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Plasticity of circadian behavior and the suprachiasmatic nucleus following exposure to non-24-hour light cycles.
pubmed:affiliation
Department of Biology, Washington University, St. Louis, MO 63130-4899, USA. sjaton@artsci.wustl.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.