Source:http://linkedlifedata.com/resource/pubmed/id/15154624
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2C
|
| pubmed:dateCreated |
2004-5-24
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| pubmed:abstractText |
This report was performed to study the biological role of c-Met in oral tumorigenesis by analyzing its expression in relation to clinicopathological features. Seventy-three cases of oral squamous cell carcinoma and 10 of normal mucosa were analysed for c-Met expression by immunohistochemistry. Normal oral squamous epithelium showed absent or low membranous positivity in the intermediate (malpighian-spinous) layer. Fifty-seven cases (78%) of carcinoma showed immunopositivity, with a prevalently membranous positivity and scattered areas also showing a cytoplasmic localization. Sixteen cases of carcinoma (22%) showed no positivity for c-Met. Among positive tumours, well-differentiated areas showed low or absent cytoplasmic positivity, while low-differentiated areas showed both membranous and cytoplasmic positivity. There was no statistically significant correlation between c-Met expression and sex, recurrence, staging or grading. The frequency of lymph node metastases was higher in c-Met-positive tumours (17/57, 29%) than in c-Met-negative ones (4/16, 25%). When analysed for prognostic significance, patients with negative/reduced c-Met expression had better survival rates than patients with high expression. The difference between survival rates was statistically significant (p<0.05). These data suggest that c-Met expression may be useful to identify cases of oral squamous cell carcinoma with a more aggressive and invasive phenotype.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0250-7005
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| pubmed:author |
pubmed-author:De RosaGG,
pubmed-author:FerrariFF,
pubmed-author:LeonardiRR,
pubmed-author:Lo MuzioLL,
pubmed-author:MignognaM DMD,
pubmed-author:PannoneGG,
pubmed-author:PieramiciTT,
pubmed-author:RubiniCC,
pubmed-author:SerpicoRR,
pubmed-author:StaibanoSS,
pubmed-author:TestaNN,
pubmed-author:TrevisiolLL
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| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1063-9
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:15154624-Adult,
pubmed-meshheading:15154624-Aged,
pubmed-meshheading:15154624-Aged, 80 and over,
pubmed-meshheading:15154624-Carcinoma, Squamous Cell,
pubmed-meshheading:15154624-Endothelium, Vascular,
pubmed-meshheading:15154624-Female,
pubmed-meshheading:15154624-Humans,
pubmed-meshheading:15154624-Immunohistochemistry,
pubmed-meshheading:15154624-Lymphatic Metastasis,
pubmed-meshheading:15154624-Male,
pubmed-meshheading:15154624-Middle Aged,
pubmed-meshheading:15154624-Mouth Mucosa,
pubmed-meshheading:15154624-Mouth Neoplasms,
pubmed-meshheading:15154624-Neoplasm Staging,
pubmed-meshheading:15154624-Prognosis,
pubmed-meshheading:15154624-Proto-Oncogene Proteins c-met,
pubmed-meshheading:15154624-Stromal Cells,
pubmed-meshheading:15154624-Tumor Markers, Biological
|
| pubmed:articleTitle |
Scatter factor receptor (c-Met) as possible prognostic factor in patients with oral squamous cell carcinoma.
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| pubmed:affiliation |
Institute of Dental Sciences, University of Ancona, Ancona, Italy. lomuziol@tin.it
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| pubmed:publicationType |
Journal Article
|