Linked Life Data

15154622

Source:http://linkedlifedata.com/resource/pubmed/id/15154622

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2C
pubmed:dateCreated
2004-5-24
pubmed:abstractText
Expression of CD44 has been identified as a prognostic factor in several malignant diseases. Few studies have correlated CD44 expression in soft tissue sarcoma with subsequent tumor progression or recurrence. We sought to investigate the clinical significance of CD44s (standard) in adult soft tissue sarcoma (STS). Tumor specimens of 62 patients with STS were evaluated by immunohistochemistry for CD44s expression. The primary outcome measures were survival and local recurrence. Of 62 analyzed specimens, 49 tumors were CD44s-positive compared to 13 CD44s-negative tumors. Kaplan-Meier survival analysis indicated significantly better survival among patients whose tumor was CD44s-positive (p=0.015). CD44s expression (hazard ratio, 3.1; 95% confidence interval, 1.5 to 7.0), tumor size (hazard ratio, 11.7; 95% confidence interval, 1.8 to 322) and resection quality (R1 vs. R0: hazard ratio, 8.7; 95% confidence interval, 3.1 to 24.5) were independent predictors of survival in multivariate analysis. CD44s expression correlates with prognosis of soft tissue sarcomas and therefore may have a pathogenetic role in tumor progression. Our results suggest that expression of CD44s in primary STS provides value regarding the progression of STS and, therefore, could be useful in selecting patients for adjuvant treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1053-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
CD44s expression is associated with improved survival in soft tissue sarcoma.
pubmed:affiliation
Department of Surgery, Universitätsklinikum Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. matthias.peiper@uni-duesseldorf.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't