rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-6-4
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pubmed:abstractText |
We have previously shown that fisetin, a flavonol, inhibits IL-4 and IL-13 synthesis by allergen- or anti-IgE-antibody-stimulated basophils. This time, we investigated the inhibition of IL-4 and IL-13 production by basophils by other flavonoids and attempted to determine the fundamental structure of flavonoids related to inhibition. We additionally investigated whether flavonoids suppress leukotriene C4 synthesis by basophils and IL-4 synthesis by T cells in response to anti-CD3 antibody.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Allergic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Apigenin,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-13,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene C4,
http://linkedlifedata.com/resource/pubmed/chemical/Luteolin,
http://linkedlifedata.com/resource/pubmed/chemical/fisetin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1018-2438
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
134
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15153793-Animals,
pubmed-meshheading:15153793-Anti-Allergic Agents,
pubmed-meshheading:15153793-Antineoplastic Agents,
pubmed-meshheading:15153793-Apigenin,
pubmed-meshheading:15153793-Basophils,
pubmed-meshheading:15153793-Biological Markers,
pubmed-meshheading:15153793-Dose-Response Relationship, Drug,
pubmed-meshheading:15153793-Flavonoids,
pubmed-meshheading:15153793-Humans,
pubmed-meshheading:15153793-Immunoglobulin E,
pubmed-meshheading:15153793-Interleukin-13,
pubmed-meshheading:15153793-Interleukin-4,
pubmed-meshheading:15153793-Leukocytes, Mononuclear,
pubmed-meshheading:15153793-Leukotriene C4,
pubmed-meshheading:15153793-Luteolin,
pubmed-meshheading:15153793-Mast Cells,
pubmed-meshheading:15153793-Rats
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pubmed:year |
2004
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pubmed:articleTitle |
Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils.
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pubmed:affiliation |
Third Department of Internal Medicine, Osaka University Medical School, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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