Linked Life Data

15153644

Source:http://linkedlifedata.com/resource/pubmed/id/15153644

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-5-21
pubmed:abstractText
Recent progress in molecular and cellular biology has developed numerous effective cardiovascular drugs. However, there are still a number of diseases for which no known effective therapy exists, such as peripheral arterial disease, ischemic heart disease, restenosis after angioplasty, vascular bypass graft occlusion, and transplant coronary vasculopathy. Currently, gene therapy is emerging as a potential strategy for the treatment of cardiovascular disease to treat such diseases despite of its limitations. The first human trial in cardiovascular disease was started in 1994 to treat peripheral vascular disease using vascular endothelial growth factor (VEGF). Since then, many different potent angiogenic growth factors have been tested in clinical trials to treat peripheral arterial disease. The results from these clinical trials seem to exceed expectations. Improvement of clinical symptoms in peripheral arterial disease and ischemic heart disease has been reported. In addition, another strategy for combating disease processes, the targeting of transcriptional processes, has been tested in a human trial. Genetically modified vein grafts transfected with decoy against E2F, an essential transcription factor in cell cycle progression, revealed apparent long-term potency in human patients. This review focuses on the future potential of gene therapy for the treatment of cardiovascular disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1347-8613
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Perspective in progress of cardiovascular gene therapy.
pubmed:affiliation
Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Japan. morishit@cgt.med.osaka-u.ac.jp
pubmed:publicationType
Journal Article, Review