| pubmed-article:15153535 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15153535 | lifeskim:mentions | umls-concept:C0024314 | lld:lifeskim |
| pubmed-article:15153535 | lifeskim:mentions | umls-concept:C0264511 | lld:lifeskim |
| pubmed-article:15153535 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:15153535 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:15153535 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:15153535 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:15153535 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15153535 | pubmed:dateCreated | 2004-5-21 | lld:pubmed |
| pubmed-article:15153535 | pubmed:abstractText | We used a PCR and sequence procedure to analyze the Ig V(H) gene and the mutations in the 5' regulatory regions of BCL-6 genes in pulmonary lymphoproliferative disorders (mucosa-associated lymphoid tissue (MALT) lymphoma, HIV-related, EBV-related, and virus-negative lymphocytic interstitial pneumonia (LIP)). Eight of 20 (40%) pulmonary MALT lymphoma and 10 of 20 LIP (5 of 5 (100%) HIV-related, 2 of 5 (40%) EBV-related, and 3 of 10 (30%) virus-negative LIP) cases showed BCL-6 gene mutations. Intraclonal heterogeneity of the BCL-6 mutations was observed only in pulmonary MALT lymphoma cases whose Ig V(H) genes also showed intraclonal heterogeneity. Ongoing BCL-6 mutations might reflect re-entry into a germinal center pathway to further mutations. BCL-6 mutations in pulmonary MALT lymphoma and HIV-negative LIP showed some features (high transition to transversion ratio, standard polarity, and RGYW/WRCY bias) of Ig V(H) gene hypermutation, leading to the view that pulmonary MALT lymphomas and HIV-negative LIP are under the influence of germinal center hypermutation mechanisms. Because BCL-6 mutations in HIV-related LIP cases did not demonstrate features of Ig V(H) gene hypermutation, immunological reactions in HIV-related LIP are the result of a process different from that found in HIV-negative pulmonary lymphoproliferative disorders. | lld:pubmed |
| pubmed-article:15153535 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153535 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153535 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15153535 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153535 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15153535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153535 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15153535 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15153535 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:KurosuKatsush... | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:YumotoNorioN | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:RomWilliam... | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:TakiguchiYuic... | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:NakataKohK | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:TatsumiKoichi... | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:WeidenMichael... | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:KuriyamaTakay... | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:JagirdarJaish... | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:MikataAtsuoA | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:KasaharaYasun... | lld:pubmed |
| pubmed-article:15153535 | pubmed:author | pubmed-author:TanabeNobuhir... | lld:pubmed |
| pubmed-article:15153535 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15153535 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15153535 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:15153535 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15153535 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15153535 | pubmed:pagination | 7116-22 | lld:pubmed |
| pubmed-article:15153535 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
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| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:meshHeading | pubmed-meshheading:15153535... | lld:pubmed |
| pubmed-article:15153535 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15153535 | pubmed:articleTitle | BCL-6 mutations in pulmonary lymphoproliferative disorders: demonstration of an aberrant immunological reaction in HIV-related lymphoid interstitial pneumonia. | lld:pubmed |
| pubmed-article:15153535 | pubmed:affiliation | Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba, Japan. kurosu@faculty.chiba-u.ac.jp | lld:pubmed |
| pubmed-article:15153535 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15153535 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15153535 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
