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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-5-21
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pubmed:abstractText |
We used a PCR and sequence procedure to analyze the Ig V(H) gene and the mutations in the 5' regulatory regions of BCL-6 genes in pulmonary lymphoproliferative disorders (mucosa-associated lymphoid tissue (MALT) lymphoma, HIV-related, EBV-related, and virus-negative lymphocytic interstitial pneumonia (LIP)). Eight of 20 (40%) pulmonary MALT lymphoma and 10 of 20 LIP (5 of 5 (100%) HIV-related, 2 of 5 (40%) EBV-related, and 3 of 10 (30%) virus-negative LIP) cases showed BCL-6 gene mutations. Intraclonal heterogeneity of the BCL-6 mutations was observed only in pulmonary MALT lymphoma cases whose Ig V(H) genes also showed intraclonal heterogeneity. Ongoing BCL-6 mutations might reflect re-entry into a germinal center pathway to further mutations. BCL-6 mutations in pulmonary MALT lymphoma and HIV-negative LIP showed some features (high transition to transversion ratio, standard polarity, and RGYW/WRCY bias) of Ig V(H) gene hypermutation, leading to the view that pulmonary MALT lymphomas and HIV-negative LIP are under the influence of germinal center hypermutation mechanisms. Because BCL-6 mutations in HIV-related LIP cases did not demonstrate features of Ig V(H) gene hypermutation, immunological reactions in HIV-related LIP are the result of a process different from that found in HIV-negative pulmonary lymphoproliferative disorders.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:JagirdarJaishreeJ,
pubmed-author:KasaharaYasunoriY,
pubmed-author:KuriyamaTakayukiT,
pubmed-author:KurosuKatsushiK,
pubmed-author:MikataAtsuoA,
pubmed-author:NakataKohK,
pubmed-author:RomWilliam NWN,
pubmed-author:TakiguchiYuichiY,
pubmed-author:TanabeNobuhiroN,
pubmed-author:TatsumiKoichiroK,
pubmed-author:WeidenMichael DMD,
pubmed-author:YumotoNorioN
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7116-22
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15153535-Adult,
pubmed-meshheading:15153535-Aged,
pubmed-meshheading:15153535-Child, Preschool,
pubmed-meshheading:15153535-DNA-Binding Proteins,
pubmed-meshheading:15153535-Female,
pubmed-meshheading:15153535-HIV Infections,
pubmed-meshheading:15153535-Humans,
pubmed-meshheading:15153535-Immunoglobulin Heavy Chains,
pubmed-meshheading:15153535-Immunoglobulin Variable Region,
pubmed-meshheading:15153535-Lung Diseases, Interstitial,
pubmed-meshheading:15153535-Lung Neoplasms,
pubmed-meshheading:15153535-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:15153535-Male,
pubmed-meshheading:15153535-Middle Aged,
pubmed-meshheading:15153535-Mutation,
pubmed-meshheading:15153535-Proto-Oncogene Proteins,
pubmed-meshheading:15153535-Proto-Oncogene Proteins c-bcl-6,
pubmed-meshheading:15153535-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
BCL-6 mutations in pulmonary lymphoproliferative disorders: demonstration of an aberrant immunological reaction in HIV-related lymphoid interstitial pneumonia.
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pubmed:affiliation |
Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba, Japan. kurosu@faculty.chiba-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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