|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2A
|
|
pubmed:dateCreated |
2004-5-21
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|
pubmed:abstractText |
Clinical drug resistance is frequently associated with overexpression of the multidrug resistance (MDR) proteins P-glycoprotein (Pgp), multidrug resistance protein (MRP-1) and breast cancer resistance protein (BCRP). Taxanes are substrates for Pgp and MRP-1, but not BCRP. Taxane-based reversal agents (tRAs) are non-cytotoxic MDR modulators previously examined for broad-spectrum modulation of Pgp, MRP-1 and BCRP.
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|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0250-7005
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
409-15
|
|
pubmed:dateRevised |
2007-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:15152938-ATP-Binding Cassette Transporters,
pubmed-meshheading:15152938-Antineoplastic Agents,
pubmed-meshheading:15152938-Cell Line, Tumor,
pubmed-meshheading:15152938-Drug Resistance, Multiple,
pubmed-meshheading:15152938-Drug Resistance, Neoplasm,
pubmed-meshheading:15152938-Humans,
pubmed-meshheading:15152938-Linear Models,
pubmed-meshheading:15152938-Neoplasm Proteins,
pubmed-meshheading:15152938-P-Glycoprotein,
pubmed-meshheading:15152938-Quantitative Structure-Activity Relationship,
pubmed-meshheading:15152938-Taxoids
|
|
pubmed:articleTitle |
Structure-activity analysis of taxane-based broad-spectrum multidrug resistance modulators.
|
|
pubmed:affiliation |
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
