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pubmed-article:1515256pubmed:abstractTextThe results of high-dose chemotherapy with melphalan or melphalan (carmustine) etoposide for 66 consecutive patients with relapsed or resistant Hodgkin's disease are described. 55 patients were evaluable for response and 22% of these achieved complete remission and 59% partial remission. The actuarial survival at 2 years was 45% and the principal factors determining survival were the sensitivity of the disease to therapy given before high-dose chemotherapy and the type of treatment received. Intensive chemotherapy with autologous bone marrow transplantation can produce long-term survivors among patients for whom long-term survival would otherwise be improbable. However, this treatment remains toxic with an uncertain place in management.lld:pubmed
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pubmed-article:1515256pubmed:articleTitleHigh-dose chemotherapy and autologous bone marrow transplantation for relapsed and refractory Hodgkin's disease.lld:pubmed
pubmed-article:1515256pubmed:affiliationYorkshire Cancer Research Campaign, Institute for Cancer Studies, St. James's University Hospital, U.K.lld:pubmed
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