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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8-9
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pubmed:dateCreated |
1992-10-8
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pubmed:abstractText |
The results of high-dose chemotherapy with melphalan or melphalan (carmustine) etoposide for 66 consecutive patients with relapsed or resistant Hodgkin's disease are described. 55 patients were evaluable for response and 22% of these achieved complete remission and 59% partial remission. The actuarial survival at 2 years was 45% and the principal factors determining survival were the sensitivity of the disease to therapy given before high-dose chemotherapy and the type of treatment received. Intensive chemotherapy with autologous bone marrow transplantation can produce long-term survivors among patients for whom long-term survival would otherwise be improbable. However, this treatment remains toxic with an uncertain place in management.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0959-8049
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28A
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
1396-400
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:1515256-Adolescent,
pubmed-meshheading:1515256-Adult,
pubmed-meshheading:1515256-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1515256-Bone Marrow Transplantation,
pubmed-meshheading:1515256-Carmustine,
pubmed-meshheading:1515256-Combined Modality Therapy,
pubmed-meshheading:1515256-Drug Administration Schedule,
pubmed-meshheading:1515256-Etoposide,
pubmed-meshheading:1515256-Female,
pubmed-meshheading:1515256-Hodgkin Disease,
pubmed-meshheading:1515256-Humans,
pubmed-meshheading:1515256-Male,
pubmed-meshheading:1515256-Melphalan,
pubmed-meshheading:1515256-Middle Aged,
pubmed-meshheading:1515256-Neoplasm Recurrence, Local,
pubmed-meshheading:1515256-Survival Rate,
pubmed-meshheading:1515256-Transplantation, Autologous
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pubmed:year |
1992
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pubmed:articleTitle |
High-dose chemotherapy and autologous bone marrow transplantation for relapsed and refractory Hodgkin's disease.
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pubmed:affiliation |
Yorkshire Cancer Research Campaign, Institute for Cancer Studies, St. James's University Hospital, U.K.
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pubmed:publicationType |
Journal Article
|