Linked Life Data

15152477

Source:http://linkedlifedata.com/resource/pubmed/id/15152477

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-5-21
pubmed:abstractText
Multipotent adult progenitor cells, which can differentiate into mesenchymal cells as well as cells with visceral mesoderm, neuroectoderm and endoderm characteristics, have been identified in the bone marrow. We examined whether bone marrow-derived cells can differentiate into the major cell types in the brain, including neuron, astrocyte, microglia and endothelium, in response to cerebral focal ischemia under treatment with cytokines. Bone marrow cells, which were sampled from green fluorescent protein (GFP)-expressing transgenic mice, were transplanted into irradiated female C57 Black/6 mice. Two months later, the recipient mice received permanent occlusion of the middle cerebral artery, then were treated with cytokines. One month after the occlusion, GFP-expressing cells, considered to be bone marrow-derived, were identified as neurons, endothelial cells, microglias and macrophages by means of NeuN, CD31, major histocompatibility complex class I antigen, and CD45 labeling, respectively, observed with confocal microscopy. These results indicate that the bone marrow-derived cells are, at least in part, a source of neurons as well as endothelial cells generated in response to cerebral infarction, in the presence of cytokines. This finding may suggest a new therapeutic strategy to enhance neuronal and vascular regeneration after stroke in the clinical field.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0009-918X
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
830-1
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Differentiation of adult bone marrow cells into neurons and endothelial cells in rat brain after stroke in the presence of cytokines].
pubmed:affiliation
Department of Neurology, Tokai University School of Medicine.
pubmed:publicationType
Journal Article, English Abstract, Review