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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8-9
|
| pubmed:dateCreated |
1992-10-8
|
| pubmed:abstractText |
The efficacy and toxicity of a high-dose multiagent consolidation regimen, OMEC (vincristine, melphalan, etoposide and carboplatin), with autologous bone marrow rescue was studied in patients with poor-prognosis neuroblastoma, 20 patients were treated with OMEC, 18 after induction chemotherapy and 2 following relapse. All patients received, per m2, vincristine 4 mg, etoposide 1 g, carboplatin 1.0-1.75 g and melphalan 180 mg followed by bone marrow rescue. 4 patients (20%) died of treatment-related complications. Severe gastrointestinal toxicity occurred in all of these patients, and in 75% of patients overall. 1 of 5 patients with evaluable disease achieved complete remission. 13 patients (65%) have relapsed a median of 10 months (range 3-26) after receiving OMEC. Thus, OMEC was not more effective, yet more toxic, than high-dose melphalan given alone, and the use of similar multiagent regimens with overlapping toxicities in advanced neuroblastoma appears inadvisable.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0959-8049
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28A
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1324-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1515243-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1515243-Bone Marrow Transplantation,
pubmed-meshheading:1515243-Carboplatin,
pubmed-meshheading:1515243-Child,
pubmed-meshheading:1515243-Child, Preschool,
pubmed-meshheading:1515243-Combined Modality Therapy,
pubmed-meshheading:1515243-Drug Administration Schedule,
pubmed-meshheading:1515243-Etoposide,
pubmed-meshheading:1515243-Female,
pubmed-meshheading:1515243-Gastrointestinal Diseases,
pubmed-meshheading:1515243-Humans,
pubmed-meshheading:1515243-Infant,
pubmed-meshheading:1515243-Male,
pubmed-meshheading:1515243-Melphalan,
pubmed-meshheading:1515243-Neuroblastoma,
pubmed-meshheading:1515243-Pilot Projects,
pubmed-meshheading:1515243-Transplantation, Autologous,
pubmed-meshheading:1515243-Vincristine
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Pilot study of high-dose vincristine, etoposide, carboplatin and melphalan with autologous bone marrow rescue in advanced neuroblastoma.
|
| pubmed:affiliation |
Paediatric Department, Royal Marsden Hospital, Sutton, Surrey, U.K.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|