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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2004-5-19
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pubmed:abstractText |
Structure-activity relationships for a recently discovered novel ribosome inhibitor (NRI) class of antibacterials were investigated. Preliminary efforts to optimize protein synthesis inhibitory activity of the series through modification of positions 3 and 4 of the naphthyridone lead template resulted in the identification of several biochemically potent analogues. A lack of corresponding whole cell antibacterial activity is thought to be a consequence of poor cellular penetration as evidenced by the enhancement of activity observed for a lead analogue tested in the presence of a cell permeabilizing agent.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BeutelBruce ABA,
pubmed-author:Black-SchaeferCandace LCL,
pubmed-author:CaiYingnaY,
pubmed-author:ChovanLinda ELE,
pubmed-author:ClarkRichard FRF,
pubmed-author:DandlikerPeter JPJ,
pubmed-author:GuYu-GuiYG,
pubmed-author:KalvinDouglasD,
pubmed-author:LernerClaude GCG,
pubmed-author:LynchLindaL,
pubmed-author:MaZhenkunZ,
pubmed-author:MotterChristopherC,
pubmed-author:NiliusAngela MAM,
pubmed-author:PrattSteve DSD,
pubmed-author:SoniNiruN,
pubmed-author:TufanoMichaelM,
pubmed-author:WagnerRolfR,
pubmed-author:WangSanyiS,
pubmed-author:WeitzbergMosheM,
pubmed-author:ZhangTianyuanT,
pubmed-author:ZhangXiaolinX
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3299-302
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pubmed:meshHeading |
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pubmed:year |
2004
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pubmed:articleTitle |
Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants.
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pubmed:affiliation |
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. rick.clark@abbott.com
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pubmed:publicationType |
Journal Article
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