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15149671
Source:
http://linkedlifedata.com/resource/pubmed/id/15149671
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Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0002482
,
umls-concept:C0018270
,
umls-concept:C0220781
,
umls-concept:C0243072
,
umls-concept:C0243077
,
umls-concept:C1424480
,
umls-concept:C1707689
,
umls-concept:C1883254
pubmed:issue
12
pubmed:dateCreated
2004-5-19
pubmed:abstractText
The rational design and synthesis of beta-amino-alpha-hydroxy amide derivatives as reversible inhibitors of methionine aminopeptidase-2 (MetAP2) with anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) is described.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amides
,
http://linkedlifedata.com/resource/pubmed/chemical/Aminopeptidases
,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins
,
http://linkedlifedata.com/resource/pubmed/chemical/METAP2 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0960-894X
pubmed:author
pubmed-author:CabuslayRonnelR
,
pubmed-author:HonigbergLeeL
,
pubmed-author:JancJames WJW
,
pubmed-author:MackmanRichard LRL
,
pubmed-author:MagillCatherineC
,
pubmed-author:SendzikMartinM
,
pubmed-author:SquiresNeilN
,
pubmed-author:WaldeckNancyN
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3181-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15149671-Amides
,
pubmed-meshheading:15149671-Aminopeptidases
,
pubmed-meshheading:15149671-Animals
,
pubmed-meshheading:15149671-Cattle
,
pubmed-meshheading:15149671-Drug Design
,
pubmed-meshheading:15149671-Endothelium, Vascular
,
pubmed-meshheading:15149671-Glycoproteins
,
pubmed-meshheading:15149671-Humans
,
pubmed-meshheading:15149671-Protease Inhibitors
pubmed:year
2004
pubmed:articleTitle
Design and synthesis of beta-amino-alpha-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth.
pubmed:affiliation
Departments of Medicinal Chemistry and Biology, Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. martin.sendzik@celera.com
pubmed:publicationType
Journal Article