| pubmed-article:15149645 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15149645 | lifeskim:mentions | umls-concept:C0042071 | lld:lifeskim |
| pubmed-article:15149645 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:15149645 | lifeskim:mentions | umls-concept:C0077913 | lld:lifeskim |
| pubmed-article:15149645 | lifeskim:mentions | umls-concept:C0053489 | lld:lifeskim |
| pubmed-article:15149645 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15149645 | pubmed:dateCreated | 2004-5-19 | lld:pubmed |
| pubmed-article:15149645 | pubmed:abstractText | Several 8-substituted 2-naphthamidine-based inhibitors of the serine protease urokinase plasminogen activator (uPA) are described. Direct attachment of five-membered saturated or unsaturated rings improved inhibitor performance; substitution with sulfones further improved binding profiles. Combination of these substituents or of previously described NH-linked heteroaromatic rings with 6-phenyl amide substituents provided further enhancements to potency and selectivity. | lld:pubmed |
| pubmed-article:15149645 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15149645 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15149645 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15149645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15149645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15149645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15149645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15149645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15149645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15149645 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15149645 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15149645 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:WendtMichael... | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:NienaberVicki... | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:RockwayTodd... | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:GirandaVincen... | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:WeitzbergMosh... | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:GeyerAndrewA | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:ZhaoXumiaoX | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:ManteiRobertR | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:StewartKentK | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:KlinghoferVer... | lld:pubmed |
| pubmed-article:15149645 | pubmed:author | pubmed-author:McClellanWill... | lld:pubmed |
| pubmed-article:15149645 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15149645 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15149645 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:15149645 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15149645 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15149645 | pubmed:pagination | 3063-8 | lld:pubmed |
| pubmed-article:15149645 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15149645 | pubmed:meshHeading | pubmed-meshheading:15149645... | lld:pubmed |
| pubmed-article:15149645 | pubmed:meshHeading | pubmed-meshheading:15149645... | lld:pubmed |
| pubmed-article:15149645 | pubmed:meshHeading | pubmed-meshheading:15149645... | lld:pubmed |
| pubmed-article:15149645 | pubmed:meshHeading | pubmed-meshheading:15149645... | lld:pubmed |
| pubmed-article:15149645 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15149645 | pubmed:articleTitle | Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors. | lld:pubmed |
| pubmed-article:15149645 | pubmed:affiliation | Cancer Research, Global Pharmaceutical R & D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA. mike.d.wendt@abbott.com | lld:pubmed |
| pubmed-article:15149645 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:15149645 | lld:chembl |
