Linked Life Data

15149158

Source:http://linkedlifedata.com/resource/pubmed/id/15149158

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-5-19
pubmed:abstractText
Survivin is a recently discovered member of the family of proteins that inhibits apoptosis. This anti-apoptotic compound can be detected in most types of cancer and expression is associated with a poor prognosis. We, immunohistochemically, investigated the expression of survivin in breast carcinomas and intraductal epithelial neoplasia of the breast to determine whether expression of this protein is associated with clinicopathological parameters such as grade, stage, mitotic rate. In 34 out of 43 cases (79.1%) of breast carcinoma and 22 out of 62 cases (35.4%) of intraductal epithelial neoplasia with mild, moderate and severe ductal epithelial, cell hyperplasia stained positively for survivin. None of the histological parameters analyzed were significantly correlated with survivin expression in breast carcinomas. In the carcinoma cases, survivin expression was positively correlated with expression of bcl-2, but was not correlated with expression of p53, bax, c-erbB-2 and estrogen, or progesterone. Some of the intraductal epithelial neoplasia cases with moderate or severe ductal epithelial hyperplasia stained positively for both survivin and p53. Breast carcinomas exhibited a significant expression of survivin, p53, and bcl-2 compared to breast with intraductal epithelial neoplasia. Survivin was not correlated with any of the clinicopathological parameters studied, however it could be a useful tool in early carcinomas and florid, severe ductal epithelial hyperplasia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0392-9078
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-12
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15149158-Breast Neoplasms, pubmed-meshheading:15149158-Carcinoma, pubmed-meshheading:15149158-Carcinoma in Situ, pubmed-meshheading:15149158-Cell Line, Tumor, pubmed-meshheading:15149158-Estrogens, pubmed-meshheading:15149158-Female, pubmed-meshheading:15149158-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15149158-Humans, pubmed-meshheading:15149158-Immunohistochemistry, pubmed-meshheading:15149158-Inhibitor of Apoptosis Proteins, pubmed-meshheading:15149158-Microtubule-Associated Proteins, pubmed-meshheading:15149158-Neoplasm Proteins, pubmed-meshheading:15149158-Progesterone, pubmed-meshheading:15149158-Prognosis, pubmed-meshheading:15149158-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:15149158-Tumor Suppressor Protein p53, pubmed-meshheading:15149158-bcl-2-Associated X Protein
pubmed:year
2004
pubmed:articleTitle
Expression of survivin, bcl-2, P53 and bax in breast carcinoma and ductal intraepithelial neoplasia (DIN 1a).
pubmed:affiliation
Dept. of Pathology, Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Adana, Turkey. faziletks@yahoo.com
pubmed:publicationType
Journal Article