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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-8-4
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pubmed:abstractText |
Alcohol dependence is characterized by the development of tolerance, withdrawal symptoms, and craving for alcohol. Chronic alcohol consumption causes neuroadaptive changes in the central dopaminergic and serotonergic system, which are partially reversible after detoxification. The severity and time-course of recovery of these neuroadaptive changes may depend on the genetic constitution of monoamine transporters and receptors and contribute to the relapse risk of alcoholics.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
561-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15148564-Alcoholism,
pubmed-meshheading:15148564-Alcohols,
pubmed-meshheading:15148564-Brain,
pubmed-meshheading:15148564-Causality,
pubmed-meshheading:15148564-Dopamine,
pubmed-meshheading:15148564-Genotype,
pubmed-meshheading:15148564-Humans,
pubmed-meshheading:15148564-Membrane Glycoproteins,
pubmed-meshheading:15148564-Membrane Transport Proteins,
pubmed-meshheading:15148564-Nerve Tissue Proteins,
pubmed-meshheading:15148564-Neural Networks (Computer),
pubmed-meshheading:15148564-Neurobiology,
pubmed-meshheading:15148564-Pharmacogenetics,
pubmed-meshheading:15148564-Phenotype,
pubmed-meshheading:15148564-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:15148564-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
2004
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pubmed:articleTitle |
Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence.
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pubmed:affiliation |
Department of Psychiatry, Campus Charité Mitte, Charité-University Medicine Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany. andreas.heinz@charite.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Review,
Research Support, Non-U.S. Gov't
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