Linked Life Data

15147908

Source:http://linkedlifedata.com/resource/pubmed/id/15147908

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2004-5-18
pubmed:abstractText
Calcium/calmodulin-dependent protein kinase I-alpha (CaMKI-alpha) is a ubiquitous cytosolic enzyme that phosphorylates a number of nuclear proteins in vitro and has been implicated in transcriptional regulation. We report that cytoplasmic localization of CaMKI-alpha depends on CRM1-mediated nuclear export mediated through a Rev-like nuclear export signal in the CaMKI-alpha regulatory domain. Interaction of CaMKI-alpha with a CRM1 complex in vitro is enhanced by incubation with calcium/calmodulin. Translocation of CaMKI-alpha into the nucleus involves a conserved sequence located within the catalytic core. Mutation of this sequence partially blocks nuclear entry of an export-impaired mutant of CaMKI-alpha.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
566
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-80
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15147908-Active Transport, Cell Nucleus, pubmed-meshheading:15147908-Animals, pubmed-meshheading:15147908-Calcium-Calmodulin-Dependent Protein Kinase Type 1, pubmed-meshheading:15147908-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:15147908-Consensus Sequence, pubmed-meshheading:15147908-Cytoplasm, pubmed-meshheading:15147908-Enzyme Activation, pubmed-meshheading:15147908-Karyopherins, pubmed-meshheading:15147908-Microscopy, Fluorescence, pubmed-meshheading:15147908-Nuclear Localization Signals, pubmed-meshheading:15147908-PC12 Cells, pubmed-meshheading:15147908-Protein Structure, Tertiary, pubmed-meshheading:15147908-Rats, pubmed-meshheading:15147908-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:15147908-Recombinant Fusion Proteins, pubmed-meshheading:15147908-Subcellular Fractions, pubmed-meshheading:15147908-Transfection
pubmed:year
2004
pubmed:articleTitle
Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-alpha depends on a nuclear export signal in its regulatory domain.
pubmed:affiliation
Department of Psychiatry, Yale University School of Medicine, 34 Park Street - 3rd Floor Research, New Haven, CT 05608, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.