Source:http://linkedlifedata.com/resource/pubmed/id/15147431
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2004-5-18
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| pubmed:abstractText |
We studied 361 patients, to evaluate risk factors for cardiac allograft vasculopathy (CAV) onset and severity/diffusion in heart transplantation (HT). Rejection scores (RS) on endomyocardial biopsy were calculated (first year and whole follow-up). CAV onset was defined as any lesion seen at yearly angiography. A CAV severity/diffusion index was calculated for each patient summing up the scores of all lesions. Cox multivariate analysis included: donor age, sex, and weight; recipient sex, age, pre-HT diagnosis, hypertension, diabetes and hyperlipidemia post-HT; number of treated rejections and RS; and immunosuppressive dosage at 3, 6, and 12 months. CAV frequency was 2% at 1 year, 22% at 5 and 39% at 10 years. Risk factors for CAV onset were older donor age [p < 0.0001, relative risk (RR) = 9.9], male donor (p < 0.001, RR = 3.2), high RS for severe (> or = 3A) grades (p < 0.02, RR = 2.01), high cyclosporine at 3 months (p < 0.02, RR = 1.9). Risk factors for CAV severity/diffusion were higher donor weight (p < 0.01, RR = 7.5), high prednisone dosage at 1 year (p < 0.0001, RR = 21.1), and coronary disease pre-HT (p < 0.002, RR = 9.7). High RS was an independent predictor for CAV onset, not severity/diffusion. This suggests an immune basis for CAV onset and nonimmune modulation for progression. High RS for severe grades may provide a predictor for patients at risk.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1600-6135
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| pubmed:author |
pubmed-author:AngeliniAnnalisaA,
pubmed-author:CaforioAlida L PAL,
pubmed-author:FeltrinGiuseppeG,
pubmed-author:FortinaAnna BelloniAB,
pubmed-author:GambinoAntonioA,
pubmed-author:GerosaGinoG,
pubmed-author:IlicetoSabinoS,
pubmed-author:PiasericoStefanoS,
pubmed-author:RamondoAngeloA,
pubmed-author:ThieneGaetanoG,
pubmed-author:TonaFrancescoF,
pubmed-author:ValenteMarialuisaM
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| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
962-70
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| pubmed:dateRevised |
2007-2-14
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| pubmed:meshHeading |
pubmed-meshheading:15147431-Adult,
pubmed-meshheading:15147431-Age of Onset,
pubmed-meshheading:15147431-Anti-Inflammatory Agents,
pubmed-meshheading:15147431-Body Weight,
pubmed-meshheading:15147431-Coronary Angiography,
pubmed-meshheading:15147431-Coronary Disease,
pubmed-meshheading:15147431-Coronary Vessels,
pubmed-meshheading:15147431-Cyclosporine,
pubmed-meshheading:15147431-Female,
pubmed-meshheading:15147431-Graft Rejection,
pubmed-meshheading:15147431-Heart Transplantation,
pubmed-meshheading:15147431-Humans,
pubmed-meshheading:15147431-Immune Tolerance,
pubmed-meshheading:15147431-Immunosuppression,
pubmed-meshheading:15147431-Immunosuppressive Agents,
pubmed-meshheading:15147431-Male,
pubmed-meshheading:15147431-Middle Aged,
pubmed-meshheading:15147431-Prednisone,
pubmed-meshheading:15147431-Prognosis,
pubmed-meshheading:15147431-Risk Factors,
pubmed-meshheading:15147431-Transplantation, Homologous
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Immune and nonimmune predictors of cardiac allograft vasculopathy onset and severity: multivariate risk factor analysis and role of immunosuppression.
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| pubmed:affiliation |
Department of Cardiology, University of Padua, Padua, Italy. alida.caforio@unipd.it
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| pubmed:publicationType |
Journal Article
|