Linked Life Data

15147296

Source:http://linkedlifedata.com/resource/pubmed/id/15147296

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-5-18
pubmed:abstractText
Semaphorins and their receptors play important roles in patterning the connectivity of the developing nervous system and recent data suggest that members of the plexin-B family of semaphorin receptors may be involved in axonal guidance. Here we show that the mRNAs of the three plexin-B genes, plxnb1, plxnb2 and plxnb3 (plexin-B1, plexin-B2 and plexin-B3), respectively, are expressed in highly specific and non-redundant patterns in peripheral and central components of the nervous system over defined periods during murine development. Whereas plexin-B1 and plexin-B2 are strongly expressed in the neuroepithelium and developing neurons, plexin-B3 mRNA is selectively localized to the white matter. Moreover, plexin-B1 and its ligand Sema4D are expressed in complementary patterns in several regions such as the developing neopallial cortex, the dorsal root ganglia and the spinal cord over embryonic stages. The Sema4d gene demonstrates a dramatic switch from prenatal expression in neuronal populations to a postnatal expression in oligodendrocytes. In contrast to its collapsing activity on growth cones of embryonic retinal ganglion cells and hippocampal neurons, soluble Sema4D enhances axonal outgrowth in embryonic cortical explants cultured in collagen matrices. Thus, plexin-B family members and Sema4D are likely to play complex and non-redundant roles during the development of the nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2622-32
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15147296-Animals, pubmed-meshheading:15147296-Animals, Newborn, pubmed-meshheading:15147296-Antigens, CD, pubmed-meshheading:15147296-Axons, pubmed-meshheading:15147296-Blotting, Northern, pubmed-meshheading:15147296-Cell Line, pubmed-meshheading:15147296-Cloning, Molecular, pubmed-meshheading:15147296-Embryo, Mammalian, pubmed-meshheading:15147296-Female, pubmed-meshheading:15147296-Gene Expression Regulation, Developmental, pubmed-meshheading:15147296-Glial Fibrillary Acidic Protein, pubmed-meshheading:15147296-Growth Cones, pubmed-meshheading:15147296-Humans, pubmed-meshheading:15147296-In Situ Hybridization, pubmed-meshheading:15147296-Kidney, pubmed-meshheading:15147296-Male, pubmed-meshheading:15147296-Membrane Glycoproteins, pubmed-meshheading:15147296-Mice, pubmed-meshheading:15147296-Nerve Tissue Proteins, pubmed-meshheading:15147296-Nervous System, pubmed-meshheading:15147296-Neurons, pubmed-meshheading:15147296-Oligodendroglia, pubmed-meshheading:15147296-Pregnancy, pubmed-meshheading:15147296-Rats, pubmed-meshheading:15147296-Receptors, Cell Surface, pubmed-meshheading:15147296-Semaphorins
pubmed:year
2004
pubmed:articleTitle
Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development.
pubmed:affiliation
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't