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rdf:type |
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lifeskim:mentions |
umls-concept:C0009325,
umls-concept:C0011644,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0076930,
umls-concept:C0205217,
umls-concept:C0205250,
umls-concept:C0332307,
umls-concept:C0332325,
umls-concept:C0456603,
umls-concept:C0597295,
umls-concept:C1880177
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pubmed:issue |
5
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|
pubmed:dateCreated |
2004-5-17
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|
pubmed:abstractText |
Aberrant transforming growth factor beta (TGFbeta) signaling has been implicated in the pathogenesis of scleroderma (systemic sclerosis [SSc]), but the contribution of specific components in this pathway to SSc fibroblast phenotype remains unclear. This study was undertaken to delineate the role of TGFbeta receptor type I (TGFbetaRI) and TGFbetaRII in collagen overexpression by SSc fibroblasts.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0004-3591
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1566-77
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15146427-Activin Receptors, Type I,
pubmed-meshheading:15146427-Adult,
pubmed-meshheading:15146427-Aged,
pubmed-meshheading:15146427-Collagen,
pubmed-meshheading:15146427-Dermis,
pubmed-meshheading:15146427-Female,
pubmed-meshheading:15146427-Fibroblasts,
pubmed-meshheading:15146427-Humans,
pubmed-meshheading:15146427-Male,
pubmed-meshheading:15146427-Middle Aged,
pubmed-meshheading:15146427-Mutagenesis,
pubmed-meshheading:15146427-Phenotype,
pubmed-meshheading:15146427-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15146427-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:15146427-Scleroderma, Systemic,
pubmed-meshheading:15146427-Signal Transduction
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pubmed:year |
2004
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pubmed:articleTitle |
An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma.
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|
pubmed:affiliation |
Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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