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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-5-17
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pubmed:abstractText |
Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3835
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pubmed:author |
pubmed-author:BogdanovaTatyana ITI,
pubmed-author:CiampiRaffaeleR,
pubmed-author:FaginJames AJA,
pubmed-author:GandhiManojM,
pubmed-author:JeremiahStephenS,
pubmed-author:KnaufJeffrey AJA,
pubmed-author:NikiforovYuri EYE,
pubmed-author:NikiforovaMarina NMN,
pubmed-author:SalvatoreGiulianaG,
pubmed-author:SantoroMassimoM,
pubmed-author:ThomasGerry AGA,
pubmed-author:TronkoMykola DMD
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
209
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15145515-Adolescent,
pubmed-meshheading:15145515-Adult,
pubmed-meshheading:15145515-Carcinoma, Papillary,
pubmed-meshheading:15145515-Child,
pubmed-meshheading:15145515-Humans,
pubmed-meshheading:15145515-Mutation,
pubmed-meshheading:15145515-Neoplasms, Radiation-Induced,
pubmed-meshheading:15145515-Point Mutation,
pubmed-meshheading:15145515-Polymerase Chain Reaction,
pubmed-meshheading:15145515-Proto-Oncogene Proteins,
pubmed-meshheading:15145515-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:15145515-Proto-Oncogene Proteins c-raf,
pubmed-meshheading:15145515-Proto-Oncogene Proteins c-ret,
pubmed-meshheading:15145515-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:15145515-Temperature,
pubmed-meshheading:15145515-Thyroid Neoplasms
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pubmed:year |
2004
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pubmed:articleTitle |
Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, OH 45267 0529, USA. yuri.nikiforov@uc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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