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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-5-14
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pubmed:abstractText |
Phosphorylated derivatives of the lipid phosphatidylinositol are known to play critical roles in insulin response. Phosphatidylinositol 5-phosphate 4-kinases convert phosphatidylinositol 5-phosphate to phosphatidylinositol 4,5-bis-phosphate. To understand the physiological role of these kinases, we generated mice that do not express phosphatidylinositol 5-phosphate 4-kinase beta. These mice are hypersensitive to insulin and have reduced body weights compared to wild-type littermates. While adult male mice lacking phosphatidylinositol 5-phosphate 4-kinase beta have significantly less body fat than wild-type littermates, female mice lacking phosphatidylinositol 5-phosphate 4-kinase beta have increased insulin sensitivity in the presence of normal adiposity. Furthermore, in vivo insulin-induced activation of the protein kinase Akt is enhanced in skeletal muscle and liver from mice lacking phosphatidylinositol 5-phosphate 4-kinase beta. These results indicate that phosphatidylinositol 5-phosphate 4-kinase beta plays a role in determining insulin sensitivity and adiposity in vivo and suggest that inhibitors of this enzyme may be useful in the treatment of type 2 diabetes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-10066179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-10660596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-10891488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-10978351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11000114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11062485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11160134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11217863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11311241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11343120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11375483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11387480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11408644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11435467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11752399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-11781359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-12110165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-12356723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-12360287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-12471165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-12788932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-12897244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-7526222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-7639683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-7969452,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-9335502,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15143198-9988280
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5080-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15143198-Adipose Tissue,
pubmed-meshheading:15143198-Animals,
pubmed-meshheading:15143198-Eating,
pubmed-meshheading:15143198-Female,
pubmed-meshheading:15143198-Insulin,
pubmed-meshheading:15143198-Leptin,
pubmed-meshheading:15143198-Male,
pubmed-meshheading:15143198-Mice,
pubmed-meshheading:15143198-Mice, Knockout,
pubmed-meshheading:15143198-Muscle, Skeletal,
pubmed-meshheading:15143198-Phosphatidylinositol Phosphates,
pubmed-meshheading:15143198-Phosphotransferases
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pubmed:year |
2004
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pubmed:articleTitle |
Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.
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pubmed:affiliation |
Beth Israel Hospital, Harvard Institutes of Medicine, Division of Signal Transduction, 10th Floor, 330 Brookline, MA 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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