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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-5-14
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pubmed:abstractText |
RRM1 has important functions in the determination of the malignant phenotype. It controls cell proliferation through deoxynucleotide production and metastatic propensity through PTEN induction. It is located in a region of loss of heterozygosity in non-small-cell lung cancer (NSCLC), which is a predictor of poor survival. We hypothesized that RRM1 expression would be a significant predictor of outcome in NSCLC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0732-183X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1878-85
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15143080-Aged,
pubmed-meshheading:15143080-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15143080-DNA Primers,
pubmed-meshheading:15143080-Disease-Free Survival,
pubmed-meshheading:15143080-Female,
pubmed-meshheading:15143080-Florida,
pubmed-meshheading:15143080-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15143080-Genetic Markers,
pubmed-meshheading:15143080-Humans,
pubmed-meshheading:15143080-Loss of Heterozygosity,
pubmed-meshheading:15143080-Lung Neoplasms,
pubmed-meshheading:15143080-Male,
pubmed-meshheading:15143080-Middle Aged,
pubmed-meshheading:15143080-Polymerase Chain Reaction,
pubmed-meshheading:15143080-Predictive Value of Tests,
pubmed-meshheading:15143080-Prognosis,
pubmed-meshheading:15143080-Proportional Hazards Models,
pubmed-meshheading:15143080-Prospective Studies,
pubmed-meshheading:15143080-Retrospective Studies,
pubmed-meshheading:15143080-Survival Analysis,
pubmed-meshheading:15143080-Tumor Suppressor Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer.
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pubmed:affiliation |
Thoracic Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9497, USA. beplerg@moffitt.usf.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Evaluation Studies
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