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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-5-14
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pubmed:abstractText |
Recently, we reported that a large number of human hepatocellular cancer (HCC) cell lines were auxotrophic for arginine. Here we report the results obtained with the amino acid-degrading enzyme arginine deiminase (ADI) conjugated to polyethylene glycol (ADI-SS PEG 20,000 mw) as a means of lowering plasma arginine to treat HCC. The study was a cohort dose-escalation phase I/II study.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:BeneduceGerardoG,
pubmed-author:BomalaskiJohn SJS,
pubmed-author:CastelloGiuseppeG,
pubmed-author:ClarkMike AMA,
pubmed-author:CremonaFrancoF,
pubmed-author:CurleySteven ASA,
pubmed-author:De RosaVincenzoV,
pubmed-author:EnsorC MarkCM,
pubmed-author:HoltsbergFrederick WFW,
pubmed-author:IzzoFrancescoF,
pubmed-author:MarraPaoloP,
pubmed-author:NgChaanC,
pubmed-author:VallonePaoloP
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pubmed:issnType |
Print
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pubmed:day |
15
|
|
pubmed:volume |
22
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1815-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15143074-Adult,
pubmed-meshheading:15143074-Aged,
pubmed-meshheading:15143074-Carcinoma, Hepatocellular,
pubmed-meshheading:15143074-Cohort Studies,
pubmed-meshheading:15143074-Disease-Free Survival,
pubmed-meshheading:15143074-Drug Administration Schedule,
pubmed-meshheading:15143074-Female,
pubmed-meshheading:15143074-Humans,
pubmed-meshheading:15143074-Hydrolases,
pubmed-meshheading:15143074-Injections, Intramuscular,
pubmed-meshheading:15143074-Liver Neoplasms,
pubmed-meshheading:15143074-Male,
pubmed-meshheading:15143074-Middle Aged,
pubmed-meshheading:15143074-Polyethylene Glycols,
pubmed-meshheading:15143074-Survival Analysis,
pubmed-meshheading:15143074-Tomography, X-Ray Computed,
pubmed-meshheading:15143074-Treatment Outcome
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pubmed:year |
2004
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pubmed:articleTitle |
Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies.
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pubmed:affiliation |
Pascale NAtional Cancer Institute, Naples, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II,
Clinical Trial, Phase I
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