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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
30
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pubmed:dateCreated |
2004-7-19
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pubmed:abstractText |
Activation of the transcription factor NF-kappaB is a hallmark of infections by viral pathogens including influenza viruses. Because gene expression of many proinflammatory and antiviral cytokines is controlled by this factor, the concept emerged that NF-kappaB and its upstream regulator IkappaB kinase are essential components of the innate antiviral immune response to infectious pathogens. In contrast to this common view we report here that NF-kappaB activity promotes efficient influenza virus production. On a molecular level this is due to NF-kappaB-dependent viral induction of the proapoptotic factors tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and FasL, which enhance virus propagation in an autocrine and paracrine fashion. Thus, NF-kappaB acts both proapoptotically and provirally in the context of an influenza virus infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CHUK protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/IKBKB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IKBKE protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30931-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15143063-Animals,
pubmed-meshheading:15143063-Antigens, CD95,
pubmed-meshheading:15143063-Apoptosis Regulatory Proteins,
pubmed-meshheading:15143063-Cell Line,
pubmed-meshheading:15143063-Cercopithecus aethiops,
pubmed-meshheading:15143063-Dogs,
pubmed-meshheading:15143063-Fas Ligand Protein,
pubmed-meshheading:15143063-Humans,
pubmed-meshheading:15143063-I-kappa B Kinase,
pubmed-meshheading:15143063-Influenza A virus,
pubmed-meshheading:15143063-Membrane Glycoproteins,
pubmed-meshheading:15143063-Mutation,
pubmed-meshheading:15143063-NF-kappa B,
pubmed-meshheading:15143063-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15143063-Signal Transduction,
pubmed-meshheading:15143063-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:15143063-Tumor Necrosis Factor-alpha,
pubmed-meshheading:15143063-Vero Cells,
pubmed-meshheading:15143063-Virus Replication
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pubmed:year |
2004
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pubmed:articleTitle |
NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation.
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pubmed:affiliation |
Institute of Molecular Medicine, Heinrich-Heine Universität, Universitätsstrasse 1, D-40225 Düsseldorf, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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