Linked Life Data

15140560

Source:http://linkedlifedata.com/resource/pubmed/id/15140560

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-5-13
pubmed:abstractText
In order to investigate temporal characteristics of oscillatory neural activity and the effect of chronic dopamine depletion on it, local field potentials were measured in anesthetized rats without or with a 6-OHDA lesion at either the ventral tegmental area or the substantia nigra compacta, using a pair of electrodes that were separated by 120 microm. Coupling of neural activity in this mesoscopic scale was measured by a synchronization index that quantified the distribution of differences in instantaneous phase between the two potentials recorded. Phase synchrony was significantly stronger at deep basal ganglia sites, more so than at cortical sites, over a gamma range (30-120 Hz) in normal rats. After chronic dopamine depletion, this synchrony was no longer observable, especially after a substantia nigra lesion, while there was an increase in phase synchrony in the cortex at a lower frequency band (10 Hz). These findings are consistent with previously reported findings that the effect of dopaminergic innervation on oscillatory neural activity varies from synchronizing to desynchronizing, depending on the structure innervated and the frequency of the oscillation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0168-0102
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Change in phase synchronization of local field potentials in anesthetized rats after chronic dopamine depletion.
pubmed:affiliation
Department of Neurology, Seoul National University, 28 Yongon-Dong Chongno-Gu, Seoul 110-744, South Korea. kminlee@ski.org
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't