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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-2-1
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pubmed:abstractText |
The aim of the present study was to investigate a putative modulation of rat 5-HT system by the muscarinic receptor antagonist atropine using in-vivo electrophysiological and behavioural techniques. In the dorsal raphe nucleus, administration of atropine (1 mg/kg i.v.) prevented the suppressant effect of the selective serotonin reuptake inhibitor paroxetine (0.5 mg/kg i.v.) on the spontaneous firing activity of 5-HT neurons, suggesting that atropine could induce an attenuation of somatodendritic 5-HT1A autoreceptors responsiveness. The 5-HT1A receptor agonist 8-OH-DPAT decreased both immobility in the forced swim test and the body core temperature. Pre-treatment with atropine (5 and 10 mg/kg i.p.) enhanced antidepressant-like effect of 8-OH-DPAT (1 mg/kg s.c.) and reduced 8-OH-DPAT (0.1 mg/kg s.c.)-induced hypothermia. In conclusion, the present study reports a functional role of muscarinic receptors in the modulation of pre- and post-synaptic 5-HT1A receptors mediated responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1461-1457
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
391-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15140278-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:15140278-Animals,
pubmed-meshheading:15140278-Atropine,
pubmed-meshheading:15140278-Body Temperature,
pubmed-meshheading:15140278-Male,
pubmed-meshheading:15140278-Motor Activity,
pubmed-meshheading:15140278-Muscarinic Antagonists,
pubmed-meshheading:15140278-Neurons,
pubmed-meshheading:15140278-Parasympathetic Nervous System,
pubmed-meshheading:15140278-Paroxetine,
pubmed-meshheading:15140278-Raphe Nuclei,
pubmed-meshheading:15140278-Rats,
pubmed-meshheading:15140278-Rats, Sprague-Dawley,
pubmed-meshheading:15140278-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:15140278-Serotonin,
pubmed-meshheading:15140278-Serotonin Receptor Agonists,
pubmed-meshheading:15140278-Serotonin Uptake Inhibitors,
pubmed-meshheading:15140278-Swimming
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pubmed:year |
2004
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pubmed:articleTitle |
In-vivo modulation of central 5-hydroxytryptamine (5-HT1A) receptor-mediated responses by the cholinergic system.
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pubmed:affiliation |
Laboratory of Neuropharmacology & Neurochemistry, Faculty of Pharmacy, University Claude Bernard Lyon I, INSERM U-512, 8 Avenue Rockefeller 69373 Lyon Cedex 08, France. nhaddj@rockefeller.univ-lyon1.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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