Linked Life Data

15137897

Source:http://linkedlifedata.com/resource/pubmed/id/15137897

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-5-12
pubmed:abstractText
Neuroblastic tumors are the most common extracranial tumors of childhood. They arise from embryonal cells committed to the development of the sympathetic nervous system. In vivo and in vitro observations have shown that neuroblastic tumors appear to recapitulate the development of differentiating sympathetic neurons and chromaffin (neuroendocrine) cells of the sympathetic nervous system. This suggests that the origin of neuroblastic tumors resides as a block in the process of differentiation. This article summarizes the experimental data accumulated over the last three decades, which has provided some clues to the cellular origin of such tumors. In order to identify the cellular origin of these tumors, the embryology of the sympathetic nervous system is first reviewed and any archeological rests of normal development in the tumors are then discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1473-7159
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-302
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Origin of neuroblastic tumors: clues for future therapeutics.
pubmed:affiliation
Department of Oncology, Hospital Sant Joan de Deu de Barcelona, Passeig de Sant Joan de Deu num 2, 08950 Barcelona, Spain. Jmora@hsjdbcn.org
pubmed:publicationType
Journal Article, Review