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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-5-11
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pubmed:abstractText |
Central nicotinic acetylcholine receptors (nAChRs) represent major neurotransmitter receptors responsible for various brain functions, and changes in the density of nAChRs have recently been reported in several neurodegenerative diseases. Visualization of nAChRs in human brain has thus been of great interest, and the development of radiopharmaceuticals for the imaging and quantitative assessment of central nAChRs has been desired. In this study, we synthesized 5-(11)C-methyl-3-(2-(S)-azetidinylmethoxy)pyridine (5MA), a derivative of 3-(2-(S)-azetidinylmethoxy)pyridine (A-85380) (11)C-methylated at position 5 of the pyridyl fragment, and evaluated its potential for investigating central nAChRs by PET.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
878-84
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15136639-Animals,
pubmed-meshheading:15136639-Azetidines,
pubmed-meshheading:15136639-Brain,
pubmed-meshheading:15136639-Carbon Radioisotopes,
pubmed-meshheading:15136639-Macaca mulatta,
pubmed-meshheading:15136639-Male,
pubmed-meshheading:15136639-Mice,
pubmed-meshheading:15136639-Radiopharmaceuticals,
pubmed-meshheading:15136639-Rats,
pubmed-meshheading:15136639-Rats, Wistar,
pubmed-meshheading:15136639-Receptors, Nicotinic,
pubmed-meshheading:15136639-Tissue Distribution,
pubmed-meshheading:15136639-Tomography, Emission-Computed
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pubmed:year |
2004
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pubmed:articleTitle |
Evaluation of 5-(11)C-methyl-A-85380 as an imaging agent for PET investigations of brain nicotinic acetylcholine receptors.
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pubmed:affiliation |
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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