Linked Life Data

15135240

Source:http://linkedlifedata.com/resource/pubmed/id/15135240

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-5-11
pubmed:abstractText
Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiogenic cells differentiate to form first vessels. These progenitor cells are thought to be directly derived from mesenchymal cells rather than originating from fetal blood cells. We investigated the relation between differentiation of stromal cells towards endothelial cells and vascular structures and the expression pattern of the respective growth factors. Using transmission electron microscopy and immunohistochemistry (for VEGF, Flt-1, Flk-1, CD14, CD34, and CD68) the development of placental vasculogenesis during very early stages of pregnancy (days 22-48 p.c.) was studied. We found that VEGF is strongly expressed in villous cytotrophoblast cells and subsequently in Hofbauer cells while its receptors Flt-1 and Flk-1 are found on vasculogenic and angiogenic precursor cells. The developmental expression and secretion of VEGF suggests its involvement in recruitment, maintenance and formation of first angiogenic cells and vessels. Interactions between VEGF and Flk-1 and Flt-1 may regulate placental vasculogenesis and angiogenesis in a paracrine and autocrine manner. The sequential expression of growth factors in different cell types may point to the fact that placental vasculogenesis and angiogenesis are clearly distinct events.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0143-4004
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
560-72
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15135240-Antigens, CD, pubmed-meshheading:15135240-Antigens, CD14, pubmed-meshheading:15135240-Antigens, CD34, pubmed-meshheading:15135240-Antigens, Differentiation, Myelomonocytic, pubmed-meshheading:15135240-Blotting, Western, pubmed-meshheading:15135240-Cell Differentiation, pubmed-meshheading:15135240-Chorionic Villi, pubmed-meshheading:15135240-Endothelial Cells, pubmed-meshheading:15135240-Female, pubmed-meshheading:15135240-Humans, pubmed-meshheading:15135240-Immunohistochemistry, pubmed-meshheading:15135240-Microscopy, Electron, pubmed-meshheading:15135240-Neovascularization, Physiologic, pubmed-meshheading:15135240-Placenta, pubmed-meshheading:15135240-Pregnancy, pubmed-meshheading:15135240-Receptors, Vascular Endothelial Growth Factor, pubmed-meshheading:15135240-Stromal Cells, pubmed-meshheading:15135240-Trophoblasts, pubmed-meshheading:15135240-Vascular Endothelial Growth Factor A, pubmed-meshheading:15135240-Vascular Endothelial Growth Factor Receptor-1, pubmed-meshheading:15135240-Vascular Endothelial Growth Factor Receptor-2
pubmed:year
2004
pubmed:articleTitle
Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and angiogenesis.
pubmed:affiliation
Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya 07070, Turkey. rdemir@akdeniz.edu.tr
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't