Linked Life Data

15135231

Source:http://linkedlifedata.com/resource/pubmed/id/15135231

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-5-11
pubmed:abstractText
Glutamate metabolism is known to be important for growth and development of the human fetus. The glutamate transporters EAAT1, EAAT2 and EAAT3 are key components of the glutamate-glutamine cycle and responsible for active transport of glutamate over the cell membrane. The placenta is thought to regulate glutamate transport during fetal development. Glutamate transporters have been found in placentae of rats, but their distribution in the human placenta is unknown. Therefore, the distribution of glutamate transporters EAAT1, EAAT2 and EAAT3 were analysed in the human placenta during normal pregnancies ending between 8 and 40 weeks of gestation and in placentae of intrauterine growth restricted infants with gestational ages between 28 and 35 weeks of pregnancy. Using immunohistochemistry, EAAT1 expression was found in the syncytiotrophoblast layer, while EAAT2 was detected in the syncytiotrophoblast layer and in endothelial cells of about 5 per cent of all fetal blood vessels. EAAT3 was observed in the endothelium of the fetal blood vessels in all placentae examined. However, expression was also found in the syncytio- and the cytotrophoblast layer of the fetal villi at 8 weeks of gestational age. The expression patterns of EAAT1, EAAT2 and EAAT3 suggest involvement in active transport of glutamate between the fetal and maternal blood circulation. No differences were found in the distribution of the glutamate transporters between control and IUGR placentae. Our data show specific localization of EAAT1, EAAT2 and EAAT3 in the human placenta during development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0143-4004
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
489-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15135231-Amino Acid Transport System X-AG, pubmed-meshheading:15135231-Endothelium, Vascular, pubmed-meshheading:15135231-Excitatory Amino Acid Transporter 1, pubmed-meshheading:15135231-Excitatory Amino Acid Transporter 2, pubmed-meshheading:15135231-Excitatory Amino Acid Transporter 3, pubmed-meshheading:15135231-Female, pubmed-meshheading:15135231-Fetal Growth Retardation, pubmed-meshheading:15135231-Fetus, pubmed-meshheading:15135231-Gestational Age, pubmed-meshheading:15135231-Glutamate Plasma Membrane Transport Proteins, pubmed-meshheading:15135231-Humans, pubmed-meshheading:15135231-Immunohistochemistry, pubmed-meshheading:15135231-Placenta, pubmed-meshheading:15135231-Pregnancy, pubmed-meshheading:15135231-Symporters, pubmed-meshheading:15135231-Tissue Distribution, pubmed-meshheading:15135231-Trophoblasts
pubmed:year
2004
pubmed:articleTitle
Distribution of glutamate transporters in the human placenta.
pubmed:affiliation
Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't