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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-5-10
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pubmed:abstractText |
Tumors develop mechanisms to escape recognition by the immune system. It has recently been demonstrated that tumors cause apoptotic death of key immune cells, including the major antigen-presenting cells, dendritic cells (DC). Elimination of DC from the tumor environment significantly diminishes development of specific immunologic responses. We have recently demonstrated that tumor-induced DC apoptosis could be prevented by overexpression of the anti-apoptotic molecule Bcl-x(L). The aim of this study was to identify extrinsic and intrinsic tumor-induced apoptotic pathways in DC by targeting different anti-apoptotic molecules, including FLIP, XIAP/hILP, dominant-negative procaspase-9 and HSP70.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1099-498X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
537-44
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15133764-Adenoviridae,
pubmed-meshheading:15133764-Animals,
pubmed-meshheading:15133764-Apoptosis,
pubmed-meshheading:15133764-Bone Marrow Cells,
pubmed-meshheading:15133764-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:15133764-Caspase 9,
pubmed-meshheading:15133764-Caspases,
pubmed-meshheading:15133764-Cell Survival,
pubmed-meshheading:15133764-Dendritic Cells,
pubmed-meshheading:15133764-Genetic Vectors,
pubmed-meshheading:15133764-HSP70 Heat-Shock Proteins,
pubmed-meshheading:15133764-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15133764-Male,
pubmed-meshheading:15133764-Melanoma,
pubmed-meshheading:15133764-Mice,
pubmed-meshheading:15133764-Mice, Inbred C57BL,
pubmed-meshheading:15133764-Mitochondria,
pubmed-meshheading:15133764-Transduction, Genetic,
pubmed-meshheading:15133764-Tumor Cells, Cultured
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pubmed:year |
2004
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pubmed:articleTitle |
Comparative analysis of dendritic cells transduced with different anti-apoptotic molecules: sensitivity to tumor-induced apoptosis.
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pubmed:affiliation |
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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