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pubmed:abstractText |
Some traits, while naturally polychotomous, are routinely dichotomized for genetic analysis. Dichotomization, intuitively, leads to a loss of power to detect linkage, as some phenotypic variability is discarded. This paper examines this power loss in the context of a trichotomous trait.
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pubmed:affiliation |
Division of Biostatistics, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. jon@wubios.wustl.edu
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