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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-10-1
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pubmed:abstractText |
Echo-planar imaging has been used to observe the dynamics of Gd-DTPA uptake in brain tumors. It has been possible to examine both vascular uptake and diffusion across the blood-brain barrier in a single experiment, by using the IR-MBEST echo-planar sequence which combines a high temporal resolution (approximately 3 s) with strong T1 weighting. To model the uptake it is necessary to know the arterial concentration of Gd-DTPA; in this study the signal in the sagittal sinus was measured to avoid the need to take repeated blood samples. The time constant for transfer across the blood-brain barrier was measured to be between 20 and 1050 s for different tumors. The results of the modeling correlated with the results of other assessments of tumor vascularity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0740-3194
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
241-58
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1513249-Adult,
pubmed-meshheading:1513249-Aged,
pubmed-meshheading:1513249-Blood-Brain Barrier,
pubmed-meshheading:1513249-Brain Neoplasms,
pubmed-meshheading:1513249-Capillary Permeability,
pubmed-meshheading:1513249-Cerebrovascular Circulation,
pubmed-meshheading:1513249-Contrast Media,
pubmed-meshheading:1513249-Diffusion,
pubmed-meshheading:1513249-Gadolinium,
pubmed-meshheading:1513249-Gadolinium DTPA,
pubmed-meshheading:1513249-Humans,
pubmed-meshheading:1513249-Image Enhancement,
pubmed-meshheading:1513249-Magnetic Resonance Imaging,
pubmed-meshheading:1513249-Male,
pubmed-meshheading:1513249-Middle Aged,
pubmed-meshheading:1513249-Organometallic Compounds,
pubmed-meshheading:1513249-Pentetic Acid,
pubmed-meshheading:1513249-Regional Blood Flow,
pubmed-meshheading:1513249-Subtraction Technique
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pubmed:year |
1992
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pubmed:articleTitle |
Dynamic studies of gadolinium uptake in brain tumors using inversion-recovery echo-planar imaging.
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pubmed:affiliation |
Department of Physics, University of Nottingham, United Kingdom.
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pubmed:publicationType |
Journal Article
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