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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-5-7
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pubmed:abstractText |
The transcription factor T-bet mediates IFN-gamma production by T(H)1 cells and suppresses T(H)2 cytokine production when ectopically expressed in polarized murine T(H)2 cells. Thus T-bet-mediated inhibition of T(H)2 cytokine production might be beneficial for the treatment of allergic diseases like asthma or atopic dermatitis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/IL18R1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18 Receptor alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/T-box transcription factor TBX21,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0091-6749
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pubmed:author |
pubmed-author:BiedermannTiloT,
pubmed-author:Carballido-PerrigNicoleN,
pubmed-author:CarballidoJosé MJM,
pubmed-author:FasslSandraS,
pubmed-author:GüntherClaudiaC,
pubmed-author:GlimcherLaurie HLH,
pubmed-author:HintereggerSonjaS,
pubmed-author:KundJuliaJ,
pubmed-author:LametschwandtnerGüntherG,
pubmed-author:SchwärzlerChristophC,
pubmed-author:SzaboSusanne JSJ
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pubmed:issnType |
Print
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
987-94
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15131585-Cell Movement,
pubmed-meshheading:15131585-Cytokines,
pubmed-meshheading:15131585-Dermatitis, Atopic,
pubmed-meshheading:15131585-Gene Expression,
pubmed-meshheading:15131585-Humans,
pubmed-meshheading:15131585-Interferon-gamma,
pubmed-meshheading:15131585-Interleukin-18 Receptor alpha Subunit,
pubmed-meshheading:15131585-Interleukin-4,
pubmed-meshheading:15131585-Interleukin-5,
pubmed-meshheading:15131585-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:15131585-Receptors, CXCR3,
pubmed-meshheading:15131585-Receptors, Chemokine,
pubmed-meshheading:15131585-Receptors, Interleukin,
pubmed-meshheading:15131585-Receptors, Interleukin-12,
pubmed-meshheading:15131585-Receptors, Interleukin-18,
pubmed-meshheading:15131585-T-Box Domain Proteins,
pubmed-meshheading:15131585-Th1 Cells,
pubmed-meshheading:15131585-Th2 Cells,
pubmed-meshheading:15131585-Transcription Factors,
pubmed-meshheading:15131585-Transfection
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pubmed:year |
2004
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pubmed:articleTitle |
Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities.
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pubmed:affiliation |
Novartis Institute for Biomedical Research-Vienna, Brunnerstrasse 59, A-1235 Vienna, Austria.
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pubmed:publicationType |
Journal Article,
In Vitro
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