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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5676
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pubmed:dateCreated |
2004-6-4
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pubmed:abstractText |
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation remains unclear. We define a new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required the genes ATG7 and beclin 1 and was induced by caspase-8 inhibition. Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Chloromethyl Ketones,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/BECN1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Becn1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Casp8 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Map2k7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RIPK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor-Interacting Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Ripk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/benzyloxycarbonyl-valyl-alanyl-(meth...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
304
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1500-2
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15131264-Amino Acid Chloromethyl Ketones,
pubmed-meshheading:15131264-Animals,
pubmed-meshheading:15131264-Apoptosis Regulatory Proteins,
pubmed-meshheading:15131264-Autophagy,
pubmed-meshheading:15131264-Caspase 8,
pubmed-meshheading:15131264-Caspases,
pubmed-meshheading:15131264-Cell Death,
pubmed-meshheading:15131264-Cell Line,
pubmed-meshheading:15131264-Cells, Cultured,
pubmed-meshheading:15131264-Humans,
pubmed-meshheading:15131264-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:15131264-MAP Kinase Kinase 7,
pubmed-meshheading:15131264-MAP Kinase Signaling System,
pubmed-meshheading:15131264-Membrane Proteins,
pubmed-meshheading:15131264-Mice,
pubmed-meshheading:15131264-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:15131264-Mitogen-Activated Protein Kinases,
pubmed-meshheading:15131264-Proteins,
pubmed-meshheading:15131264-RNA Interference,
pubmed-meshheading:15131264-Receptor-Interacting Protein Serine-Threonine Kinases
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pubmed:year |
2004
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pubmed:articleTitle |
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8.
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pubmed:affiliation |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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