Linked Life Data

15131020

Source:http://linkedlifedata.com/resource/pubmed/id/15131020

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-7-21
pubmed:abstractText
The nuclear receptor peroxisome proliferator-activated receptor (PPAR)gamma modulates the expression of numerous genes involved in glucose and lipid homeostasis and plays a critical role in adipocyte differentiation. Expression of uncoupling protein (UCP)1, which is necessary for thermogenesis, is strongly stimulated by PPARgamma agonists but without an increase in energy expenditure. This study was designed to assess whether PPARgamma-induced UCP1 has any functional impact and, if so, whether it involves sympathetic activity. In a first phase, obese ob/ob C57BL/6J mice and lean controls were treated for 2 wk with the PPARgamma agonist [2-(2-[4-phenoxy-2-propylphenoxy]ethyl)indole-5-acetic acid] (COOH). COOH induced UCP1 expression in brown and white adipose tissues as well as that of other genes associated with substrate oxidation and thermogenesis. However, UCP1 induction did not increase energy expenditure, as assessed by indirect calorimetry and other energy balance measurements. In a second phase, mice received for an additional 2 wk a combination of COOH and the beta(3)-adrenergic receptor (beta(3)-AR) agonist CL-316243 to stimulate the adrenergic signaling pathway and assess whether COOH-induced UCP1 was physiologically functional. The beta(3)-AR agonist stimulated thermogenesis in lean and ob/ob mice, an effect that was much stronger in COOH-pretreated mice, which exhibited lower respiratory quotient, higher oxygen consumption, and marked weight and fat mass loss, compared with mice not pretreated with COOH. These results demonstrate that PPARgamma agonism increases the thermogenic potential of white and brown adipose depots in lean and obese mice. This enhanced capacity leads to increased thermogenesis under beta-adrenergic stimulation, suggesting that the sympathetic drive is blunted by PPARgamma agonism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3925-34
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15131020-Adipose Tissue, pubmed-meshheading:15131020-Animals, pubmed-meshheading:15131020-Base Sequence, pubmed-meshheading:15131020-Body Composition, pubmed-meshheading:15131020-Energy Metabolism, pubmed-meshheading:15131020-Female, pubmed-meshheading:15131020-Ion Channels, pubmed-meshheading:15131020-Membrane Proteins, pubmed-meshheading:15131020-Mice, pubmed-meshheading:15131020-Mice, Inbred C57BL, pubmed-meshheading:15131020-Mice, Obese, pubmed-meshheading:15131020-Mitochondrial Proteins, pubmed-meshheading:15131020-Molecular Sequence Data, pubmed-meshheading:15131020-Obesity, pubmed-meshheading:15131020-Plant Proteins, pubmed-meshheading:15131020-Receptors, Adrenergic, beta-3, pubmed-meshheading:15131020-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:15131020-Transcription Factors, pubmed-meshheading:15131020-Triglycerides
pubmed:year
2004
pubmed:articleTitle
Peroxisome proliferator-activated receptor gamma agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice.
pubmed:affiliation
Department of Anatomy and Physiology, School of Medicine, Laval University, Québec, Canada G1K 7P4.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't