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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-5-7
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pubmed:abstractText |
Many eukaryotic transcripts have been reported to contain sequences similar or complementary to ribosomal RNAs. Past computational and experimental analyses have suggested a possible functional role of such rRNA-like sequences in the regulation of translation. Here, we analysed the occurrence and abundance of rRNA-like sequences in human transcripts. Using the wealth of data from genome and EST sequences, our study indicates that mRNA sequences with long highly similar rRNA-like sequences are most likely artifacts. In contrast, analysis of the occurrence of 9-nt sequences covering the entire direct and complementary 18S human rRNA sequence, revealed that many of them are significantly over- or underrepresented, suggesting their possible involvement in post-transcriptional regulation of gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1175-5636
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15130841-3' Untranslated Regions,
pubmed-meshheading:15130841-5' Untranslated Regions,
pubmed-meshheading:15130841-Base Sequence,
pubmed-meshheading:15130841-Computational Biology,
pubmed-meshheading:15130841-Databases, Nucleic Acid,
pubmed-meshheading:15130841-Expressed Sequence Tags,
pubmed-meshheading:15130841-Genomics,
pubmed-meshheading:15130841-Models, Molecular,
pubmed-meshheading:15130841-Molecular Sequence Data,
pubmed-meshheading:15130841-Nucleic Acid Conformation,
pubmed-meshheading:15130841-RNA, Messenger,
pubmed-meshheading:15130841-RNA, Ribosomal,
pubmed-meshheading:15130841-RNA, Ribosomal, 18S,
pubmed-meshheading:15130841-RNA Processing, Post-Transcriptional,
pubmed-meshheading:15130841-Sequence Alignment
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pubmed:year |
2002
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pubmed:articleTitle |
rRNA-like sequences in human mRNAs.
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pubmed:affiliation |
Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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