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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-5-7
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pubmed:abstractText |
Serotonin (5-HT) receptor 2A (5-HT2A) and 2C (5-HT2C) agonists have been reported to facilitate female rat lordosis behaviour. This study investigated the acute effects of the 5-HT2A receptor agonist DOI ((+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) and the 5-HT2C receptor agonist MK-212 (2-chloro-6-(1-piperazinyl) pyrazine) on paced mating behaviour in a population of sexually receptive female rats in order to explore the role of 5-HT2A and 5-HT2C receptors in the mediation of female rat sexual motivation. DOI (0.5 and 1.0 mg/kg) increased female rat sexual motivation during the first of two consecutive copulatory series seen as a tendency towards a decrease in return latencies following ejaculation and decreased inter-intromission intervals. MK-212 generally increased approach latencies. 0.5 mg/kg MK-212 increased post-ejaculatory exit latency, while 1.0 and 2.0 mg/kg MK-212 increased both post-ejaculatory exit latencies and post-ejaculatory return latencies. The possibility that an increased level of anxiety confounded the effects of MK-212 on sexual motivation behaviour is discussed. The results may support the hypothesis that both 5-HT2A and 5-HT2C receptors are important in regulation of female sexual behaviour.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-iodo-2,5-dimethoxyphenylisopropyla...,
http://linkedlifedata.com/resource/pubmed/chemical/Amphetamines,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/MK 212,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2C,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin 5-HT2 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/estradiol 3-benzoate
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0166-4328
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15129779-Amphetamines,
pubmed-meshheading:15129779-Animals,
pubmed-meshheading:15129779-Dose-Response Relationship, Drug,
pubmed-meshheading:15129779-Estradiol,
pubmed-meshheading:15129779-Female,
pubmed-meshheading:15129779-Male,
pubmed-meshheading:15129779-Motivation,
pubmed-meshheading:15129779-Progesterone,
pubmed-meshheading:15129779-Pyrazines,
pubmed-meshheading:15129779-Rats,
pubmed-meshheading:15129779-Rats, Wistar,
pubmed-meshheading:15129779-Reaction Time,
pubmed-meshheading:15129779-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:15129779-Receptor, Serotonin, 5-HT2C,
pubmed-meshheading:15129779-Serotonin 5-HT2 Receptor Agonists,
pubmed-meshheading:15129779-Serotonin Receptor Agonists,
pubmed-meshheading:15129779-Sexual Behavior, Animal,
pubmed-meshheading:15129779-Statistics, Nonparametric
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pubmed:year |
2004
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pubmed:articleTitle |
Different roles of 5-HT2A and 5-HT2C receptors in regulation of female rat paced mating behaviour.
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pubmed:affiliation |
Laboratory of Neuropsychiatry, Department of Psychiatry, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. per@nedergaard.org
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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