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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-6-16
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pubmed:abstractText |
Several studies have shown antifibrotic effects of angiotensin converting enzyme (ACE) inhibitors as well as of angiotensin receptor 1 (AT1) antagonists, however, prospective trials with clinical end points comparing these effects do not exist. COL4A3-/- mice develop a non-hypertensive progressive renal fibrosis. We used this animal model to compare the potential of ACE inhibitor vs AT1 antagonist to prevent renal fibrosis irrespective of blood pressure-dependent involvement by the renin system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0931-0509
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1716-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15128880-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:15128880-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:15128880-Animals,
pubmed-meshheading:15128880-Benzimidazoles,
pubmed-meshheading:15128880-Disease Models, Animal,
pubmed-meshheading:15128880-Fibrosis,
pubmed-meshheading:15128880-Hypertension, Renal,
pubmed-meshheading:15128880-Kidney,
pubmed-meshheading:15128880-Mice,
pubmed-meshheading:15128880-Ramipril,
pubmed-meshheading:15128880-Tetrazoles,
pubmed-meshheading:15128880-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis.
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pubmed:affiliation |
Medical Faculty University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany. oliver.gross@uni-koeln.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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