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rdf:type |
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lifeskim:mentions |
umls-concept:C0005821,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C0600431,
umls-concept:C0679058,
umls-concept:C1306235,
umls-concept:C1335280,
umls-concept:C1514562,
umls-concept:C1547699,
umls-concept:C1706044,
umls-concept:C2349975,
umls-concept:C2700640
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pubmed:issue |
10
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pubmed:dateCreated |
2004-5-6
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pubmed:abstractText |
To date, immunoreceptor tyrosine-based inhibition motifs (ITIMs) have been shown to mediate inhibitory properties. We report a novel triggering receptor expressed on myeloid cells (TREM) family member, TREM-like transcript-1 (TLT1), which differs from the activating members because its cytoplasmic tail contains two ITIMs at Y245 and Y281. A TLT1 splice variant (TLT1sp) encodes a different cytoplasmic tail lacking ITIMs. Both isoforms are expressed in resting platelet alpha-granules, which are up-regulated to the cell surface following activation. TLT1 recruited Src homology 2 domain-containing tyrosine phosphatase (SHP)-2 to the "classical" ITIM (Y281) but not the "nonclassical" ITIM (Y245). In contrast to previously characterized ITIM receptors, TLT1 enhanced, rather than inhibited, FcepsilonRI-mediated calcium signaling in rat basophilic leukemia cells, a property dependent on the SHP-2 recruiting classical Y281 ITIM. Therefore, TLT1 represents a new costimulatory ITIM immunoreceptor and is the second ITIM-bearing receptor to be identified in platelets after platelet endothelial cell adhesion molecule-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/PTPN11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn11 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/SH2 Domain-Containing Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/TREM1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/thrombin receptor peptide SFLLRNP
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:AlexanderDenis RDR,
pubmed-author:AstoulEmmanuelleE,
pubmed-author:BarrowAlexander DAD,
pubmed-author:BrookeGaryG,
pubmed-author:FarndaleRichard WRW,
pubmed-author:FlotoAndresA,
pubmed-author:JenningsNicola SNS,
pubmed-author:OuwehandWillemW,
pubmed-author:RelouIngrid A MIA,
pubmed-author:SmithKenneth G CKG,
pubmed-author:TrowsdaleJohnJ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5838-42
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15128762-Alternative Splicing,
pubmed-meshheading:15128762-Amino Acid Motifs,
pubmed-meshheading:15128762-Animals,
pubmed-meshheading:15128762-Blood Platelets,
pubmed-meshheading:15128762-Calcium Signaling,
pubmed-meshheading:15128762-Cell Line, Tumor,
pubmed-meshheading:15128762-Cell Membrane,
pubmed-meshheading:15128762-Cytoplasmic Granules,
pubmed-meshheading:15128762-Down-Regulation,
pubmed-meshheading:15128762-Gene Expression Regulation,
pubmed-meshheading:15128762-Humans,
pubmed-meshheading:15128762-Interphase,
pubmed-meshheading:15128762-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15128762-Membrane Glycoproteins,
pubmed-meshheading:15128762-Molecular Weight,
pubmed-meshheading:15128762-P-Selectin,
pubmed-meshheading:15128762-Peptide Fragments,
pubmed-meshheading:15128762-Protein Isoforms,
pubmed-meshheading:15128762-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:15128762-Protein Tyrosine Phosphatases,
pubmed-meshheading:15128762-Rats,
pubmed-meshheading:15128762-Receptors, IgE,
pubmed-meshheading:15128762-Receptors, Immunologic,
pubmed-meshheading:15128762-SH2 Domain-Containing Protein Tyrosine Phosphatases,
pubmed-meshheading:15128762-Tyrosine,
pubmed-meshheading:15128762-Up-Regulation,
pubmed-meshheading:15128762-src Homology Domains
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pubmed:year |
2004
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pubmed:articleTitle |
Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.
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pubmed:affiliation |
Cambridge Institute for Medical Research, Wellcome Trust, Addenbrookes Hospital, Cambridge, United Kingdom. adb44@cam.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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