| pubmed-article:15126369 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15126369 | lifeskim:mentions | umls-concept:C0019829 | lld:lifeskim |
| pubmed-article:15126369 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15126369 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:15126369 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:15126369 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:15126369 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15126369 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15126369 | pubmed:dateCreated | 2004-5-5 | lld:pubmed |
| pubmed-article:15126369 | pubmed:abstractText | Recent studies have demonstrated that the malignant Reed-Sternberg cells of Hodgkin's lymphoma (HL) secrete and are responsive to interleukin (IL)-13. We hypothesized that overexpression of a soluble IL-13 decoy receptor (sIL-13Ralpha2) via adenoviral-mediated gene transfer would inhibit IL-13-induced Reed-Sternberg cell proliferation. Western blot and ELISA analysis verified expression of sIL-13Ralpha2 in cell lysates and supernatants of AdsIL-13Ralpha2-transduced COS-7 cells. Treatment of two IL-13-responsive HL-derived cell lines, HDLM-2 and L-1236, with AdsIL-13Ralpha2-conditioned medium, resulted in the inhibition of cell proliferation, and down-regulated the phosphorylation of signal transducer and activator of transcription 6 (STAT6), an important mediator of IL-13 signaling. i.v. delivery of AdsIL-13Ralpha2 in NOD/SCID mice with s.c. implanted HDLM-2 cells delayed tumor onset and growth while enhancing survival compared with control mice. Intratumoral administration of AdsIL-13Ralpha2 led to the regression or stabilization of established tumors and was associated with diminished STAT6 phosphorylation. Our data demonstrate that AdsIL-13Ralpha2 can suppress HL growth in vitro and in vivo. | lld:pubmed |
| pubmed-article:15126369 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15126369 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15126369 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15126369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15126369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15126369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15126369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15126369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15126369 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15126369 | pubmed:month | May | lld:pubmed |
| pubmed-article:15126369 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:SkinniderBria... | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:MakTak WTW | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:LiZhihuaZ | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:StewartA... | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:ClaudioJaime... | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:Masih-KhanEst... | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:McCartJ... | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:TrudelSuzanne... | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:WenXiao-YanXY | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:BrayMark RMR | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:ZhuYuan-XiaoY... | lld:pubmed |
| pubmed-article:15126369 | pubmed:author | pubmed-author:TrieuYoungY | lld:pubmed |
| pubmed-article:15126369 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15126369 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15126369 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:15126369 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15126369 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15126369 | pubmed:pagination | 3271-5 | lld:pubmed |
| pubmed-article:15126369 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15126369 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15126369 | pubmed:articleTitle | Soluble interleukin-13Ralpha2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo. | lld:pubmed |
| pubmed-article:15126369 | pubmed:affiliation | Division of Experimental Therapeutics, Toronto General Research Institute, McLaughlin Centre for Molecular Medicine, Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:15126369 | pubmed:publicationType | Journal Article | lld:pubmed |
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