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rdf:type |
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lifeskim:mentions |
umls-concept:C0036751,
umls-concept:C0038477,
umls-concept:C0060850,
umls-concept:C0205314,
umls-concept:C0205549,
umls-concept:C0220781,
umls-concept:C0243072,
umls-concept:C0243076,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C1883254
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pubmed:issue |
11
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pubmed:dateCreated |
2004-5-5
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pubmed:abstractText |
Following the program started at Johnson & Johnson Pharmaceutical Research & Development searching for 5-HT(2A/2C) antagonists we now report on the synthesis of a series of substituted 2-(aminomethyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives. The 5-HT2A, 5-HT2C and H1 receptor affinities of the described compounds are reported. The mCCP antagonistic activity of a set of selected molecules is also reported.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AlonsoJosé MJM,
pubmed-author:AndrésJosé IJI,
pubmed-author:CidJoséJ,
pubmed-author:FernándezJavierJ,
pubmed-author:GilPilarP,
pubmed-author:IturrinoLauraL,
pubmed-author:MatesanzEncarnaE,
pubmed-author:MeertTheo FTF,
pubmed-author:MegensAntonA,
pubmed-author:SipidoVictor KVK,
pubmed-author:TrabancoAndrés AAA
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|
pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2765-71
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
|
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pubmed:year |
2004
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pubmed:articleTitle |
Synthesis and structure-activity relationship of 2-(aminoalkyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT(2A/2C) receptor antagonists.
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pubmed:affiliation |
Johnson & Johnson Pharmaceutical Research & Development, a division of Janssen-Cilag, Medicinal Chemistry Department, Jarama s/n, 45007 Toledo, Spain. jcid@prdes.jnj.com
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pubmed:publicationType |
Journal Article
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